Prefrontal cortex development in health and disease: lessons from rodents and humans

M Chini, IL Hanganu-Opatz - Trends in neurosciences, 2021 - cell.com
The role of the prefrontal cortex (PFC) takes center stage among unanswered questions in
modern neuroscience. The PFC has a Janus-faced nature: it enables sophisticated cognitive …

Current findings and perspectives on aberrant neural oscillations in schizophrenia

Y Hirano, PJ Uhlhaas - Psychiatry and clinical neurosciences, 2021 - Wiley Online Library
There is now consistent evidence that neural oscillation at low‐and high‐frequencies
constitute an important aspect of the pathophysiology of schizophrenia. Specifically …

Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling

M Richter, N Murtaza, R Scharrenberg, SH White… - Molecular …, 2019 - nature.com
Atypical brain connectivity is a major contributor to the pathophysiology of
neurodevelopmental disorders (NDDs) including autism spectrum disorders (ASDs). TAOK2 …

Olfactory bulb activity shapes the development of entorhinal-hippocampal coupling and associated cognitive abilities

YN Chen, JK Kostka, SH Bitzenhofer… - Current Biology, 2023 - cell.com
The interplay between olfaction and higher cognitive processing has been documented in
the adult brain; however, its development is poorly understood. In mice, shortly after birth …

[HTML][HTML] The impact of maternal immune activation on GABAergic interneuron development: A systematic review of rodent studies and their translational implications

B Gillespie, S Panthi, S Sundram, RA Hill - Neuroscience & Biobehavioral …, 2024 - Elsevier
Mothers exposed to infections during pregnancy disproportionally birth children who
develop autism and schizophrenia, disorders associated with altered GABAergic function …

[HTML][HTML] A transient developmental increase in prefrontal activity alters network maturation and causes cognitive dysfunction in adult mice

SH Bitzenhofer, JA Pöpplau, M Chini, A Marquardt… - Neuron, 2021 - cell.com
Disturbed neuronal activity in neuropsychiatric pathologies emerges during development
and might cause multifold neuronal dysfunction by interfering with apoptosis, dendritic …

A developmental increase of inhibition promotes the emergence of hippocampal ripples

I Pochinok, TM Stöber, J Triesch, M Chini… - Nature …, 2024 - nature.com
Sharp wave-ripples (SPW-Rs) are a hippocampal network phenomenon critical for memory
consolidation and planning. SPW-Rs have been extensively studied in the adult brain, yet …

Gamma activity accelerates during prefrontal development

SH Bitzenhofer, JA Pöpplau, I Hanganu-Opatz - elife, 2020 - elifesciences.org
Gamma oscillations are a prominent activity pattern in the cerebral cortex. While gamma
rhythms have been extensively studied in the adult prefrontal cortex in the context of …

Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice

S Schepanski, M Chini, V Sternemann… - Nature …, 2022 - nature.com
Life-long brain function and mental health are critically determined by developmental
processes occurring before birth. During mammalian pregnancy, maternal cells are …

Resolving and rescuing developmental miswiring in a mouse model of cognitive impairment

M Chini, JA Pöpplau, C Lindemann, L Carol-Perdiguer… - Neuron, 2020 - cell.com
Cognitive deficits, core features of mental illness, largely result from dysfunction of prefrontal
networks. This dysfunction emerges during early development, before a detectable …