Prefrontal cortex development in health and disease: lessons from rodents and humans
M Chini, IL Hanganu-Opatz - Trends in neurosciences, 2021 - cell.com
The role of the prefrontal cortex (PFC) takes center stage among unanswered questions in
modern neuroscience. The PFC has a Janus-faced nature: it enables sophisticated cognitive …
modern neuroscience. The PFC has a Janus-faced nature: it enables sophisticated cognitive …
Current findings and perspectives on aberrant neural oscillations in schizophrenia
There is now consistent evidence that neural oscillation at low‐and high‐frequencies
constitute an important aspect of the pathophysiology of schizophrenia. Specifically …
constitute an important aspect of the pathophysiology of schizophrenia. Specifically …
Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling
M Richter, N Murtaza, R Scharrenberg, SH White… - Molecular …, 2019 - nature.com
Atypical brain connectivity is a major contributor to the pathophysiology of
neurodevelopmental disorders (NDDs) including autism spectrum disorders (ASDs). TAOK2 …
neurodevelopmental disorders (NDDs) including autism spectrum disorders (ASDs). TAOK2 …
Olfactory bulb activity shapes the development of entorhinal-hippocampal coupling and associated cognitive abilities
The interplay between olfaction and higher cognitive processing has been documented in
the adult brain; however, its development is poorly understood. In mice, shortly after birth …
the adult brain; however, its development is poorly understood. In mice, shortly after birth …
[HTML][HTML] The impact of maternal immune activation on GABAergic interneuron development: A systematic review of rodent studies and their translational implications
Mothers exposed to infections during pregnancy disproportionally birth children who
develop autism and schizophrenia, disorders associated with altered GABAergic function …
develop autism and schizophrenia, disorders associated with altered GABAergic function …
[HTML][HTML] A transient developmental increase in prefrontal activity alters network maturation and causes cognitive dysfunction in adult mice
Disturbed neuronal activity in neuropsychiatric pathologies emerges during development
and might cause multifold neuronal dysfunction by interfering with apoptosis, dendritic …
and might cause multifold neuronal dysfunction by interfering with apoptosis, dendritic …
A developmental increase of inhibition promotes the emergence of hippocampal ripples
Sharp wave-ripples (SPW-Rs) are a hippocampal network phenomenon critical for memory
consolidation and planning. SPW-Rs have been extensively studied in the adult brain, yet …
consolidation and planning. SPW-Rs have been extensively studied in the adult brain, yet …
Gamma activity accelerates during prefrontal development
Gamma oscillations are a prominent activity pattern in the cerebral cortex. While gamma
rhythms have been extensively studied in the adult prefrontal cortex in the context of …
rhythms have been extensively studied in the adult prefrontal cortex in the context of …
Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice
S Schepanski, M Chini, V Sternemann… - Nature …, 2022 - nature.com
Life-long brain function and mental health are critically determined by developmental
processes occurring before birth. During mammalian pregnancy, maternal cells are …
processes occurring before birth. During mammalian pregnancy, maternal cells are …
Resolving and rescuing developmental miswiring in a mouse model of cognitive impairment
Cognitive deficits, core features of mental illness, largely result from dysfunction of prefrontal
networks. This dysfunction emerges during early development, before a detectable …
networks. This dysfunction emerges during early development, before a detectable …