l-Aspartate: An Essential Metabolite for Plant Growth and Stress Acclimation

M Han, C Zhang, P Suglo, S Sun, M Wang, T Su - Molecules, 2021 - mdpi.com
L-aspartate (Asp) serves as a central building block, in addition to being a constituent of
proteins, for many metabolic processes in most organisms, such as biosynthesis of other …

The druggability of solute carriers

WW Wang, L Gallo, A Jadhav, R Hawkins… - Journal of medicinal …, 2019 - ACS Publications
The transport of materials across membranes is a vital process for all aspects of cellular
function, including growth, metabolism, and communication. Protein transporters are the …

A medicinal chemistry perspective on excitatory amino acid transporter 2 dysfunction in neurodegenerative diseases

IC Fontana, DG Souza, DO Souza, A Gee… - Journal of medicinal …, 2023 - ACS Publications
The excitatory amino acid transporter 2 (EAAT2) plays a key role in the clearance and
recycling of glutamate-the major excitatory neurotransmitter in the mammalian brain. EAAT2 …

[HTML][HTML] Excitatory amino acid transporter supports inflammatory macrophage responses

Z Gan, Y Guo, M Zhao, Y Ye, Y Liao, B Liu, J Yin… - Science Bulletin, 2024 - Elsevier
Excitatory amino acid transporters (EAATs) are responsible for excitatory amino acid
transportation and are associated with auto-immune diseases in the central nervous system …

Structural aspects of photopharmacology: insight into the binding of photoswitchable and photocaged inhibitors to the glutamate transporter homologue

V Arkhipova, H Fu, MWH Hoorens… - Journal of the …, 2021 - ACS Publications
Photopharmacology addresses the challenge of drug selectivity and side effects through
creation of photoresponsive molecules activated with light with high spatiotemporal …

Iron‐Catalyzed Highly Enantioselective cis‐Dihydroxylation of Trisubstituted Alkenes with Aqueous H2O2

J Wei, L Wu, HX Wang, X Zhang… - Angewandte Chemie …, 2020 - Wiley Online Library
Reliable methods for enantioselective cis‐dihydroxylation of trisubstituted alkenes are
scarce. The iron (II) complex cis‐α‐[FeII (2‐Me2‐BQPN)(OTf) 2], which bears a tetradentate …

Biocatalytic Asymmetric Synthesis of N-Aryl-Functionalized Amino Acids and Substituted Pyrazolidinones

H Fu, A Prats Luján, L Bothof, J Zhang, PG Tepper… - ACS …, 2019 - ACS Publications
N-arylated α-amino acids and pyrazolidin-3-ones are widely being used as chiral building
blocks for pharmaceuticals and agrochemicals. Here we report a biocatalytic route for the …

Pyridoxal-catalyzed racemization of α-aminoketones enables the stereodivergent synthesis of 1, 2-amino alcohols using ketoreductases

J Cao, TK Hyster - ACS Catalysis, 2020 - ACS Publications
Differentially substituted 1, 2-amino alcohols are a prevalent motif in a variety of
pharmaceutical and agrochemical molecules. Dynamic kinetic resolutions (DKRs) that …

Chemoenzymatic multistep retrosynthesis with transformer loops

D Kreutter, JL Reymond - Chemical Science, 2024 - pubs.rsc.org
Integrating enzymatic reactions into computer-aided synthesis planning (CASP) should help
devise more selective, economical, and greener synthetic routes. Herein we report the triple …

Biocatalytic Enantioselective Hydroaminations for Production of N‐Cycloalkyl‐Substituted L‐Aspartic Acids Using Two C−N Lyases

J Zhang, H Fu, PG Tepper… - Advanced Synthesis & …, 2019 - Wiley Online Library
N‐cycloalkyl‐substituted amino acids have wide‐ranging applications in pharma‐and
nutraceutical fields. Here we report the asymmetric synthesis of various N‐cycloalkyl …