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l-Aspartate: An Essential Metabolite for Plant Growth and Stress Acclimation
L-aspartate (Asp) serves as a central building block, in addition to being a constituent of
proteins, for many metabolic processes in most organisms, such as biosynthesis of other …
proteins, for many metabolic processes in most organisms, such as biosynthesis of other …
The druggability of solute carriers
The transport of materials across membranes is a vital process for all aspects of cellular
function, including growth, metabolism, and communication. Protein transporters are the …
function, including growth, metabolism, and communication. Protein transporters are the …
A medicinal chemistry perspective on excitatory amino acid transporter 2 dysfunction in neurodegenerative diseases
The excitatory amino acid transporter 2 (EAAT2) plays a key role in the clearance and
recycling of glutamate-the major excitatory neurotransmitter in the mammalian brain. EAAT2 …
recycling of glutamate-the major excitatory neurotransmitter in the mammalian brain. EAAT2 …
[HTML][HTML] Excitatory amino acid transporter supports inflammatory macrophage responses
Z Gan, Y Guo, M Zhao, Y Ye, Y Liao, B Liu, J Yin… - Science Bulletin, 2024 - Elsevier
Excitatory amino acid transporters (EAATs) are responsible for excitatory amino acid
transportation and are associated with auto-immune diseases in the central nervous system …
transportation and are associated with auto-immune diseases in the central nervous system …
Structural aspects of photopharmacology: insight into the binding of photoswitchable and photocaged inhibitors to the glutamate transporter homologue
Photopharmacology addresses the challenge of drug selectivity and side effects through
creation of photoresponsive molecules activated with light with high spatiotemporal …
creation of photoresponsive molecules activated with light with high spatiotemporal …
Iron‐Catalyzed Highly Enantioselective cis‐Dihydroxylation of Trisubstituted Alkenes with Aqueous H2O2
Reliable methods for enantioselective cis‐dihydroxylation of trisubstituted alkenes are
scarce. The iron (II) complex cis‐α‐[FeII (2‐Me2‐BQPN)(OTf) 2], which bears a tetradentate …
scarce. The iron (II) complex cis‐α‐[FeII (2‐Me2‐BQPN)(OTf) 2], which bears a tetradentate …
Biocatalytic Asymmetric Synthesis of N-Aryl-Functionalized Amino Acids and Substituted Pyrazolidinones
N-arylated α-amino acids and pyrazolidin-3-ones are widely being used as chiral building
blocks for pharmaceuticals and agrochemicals. Here we report a biocatalytic route for the …
blocks for pharmaceuticals and agrochemicals. Here we report a biocatalytic route for the …
Pyridoxal-catalyzed racemization of α-aminoketones enables the stereodivergent synthesis of 1, 2-amino alcohols using ketoreductases
Differentially substituted 1, 2-amino alcohols are a prevalent motif in a variety of
pharmaceutical and agrochemical molecules. Dynamic kinetic resolutions (DKRs) that …
pharmaceutical and agrochemical molecules. Dynamic kinetic resolutions (DKRs) that …
Chemoenzymatic multistep retrosynthesis with transformer loops
Integrating enzymatic reactions into computer-aided synthesis planning (CASP) should help
devise more selective, economical, and greener synthetic routes. Herein we report the triple …
devise more selective, economical, and greener synthetic routes. Herein we report the triple …
Biocatalytic Enantioselective Hydroaminations for Production of N‐Cycloalkyl‐Substituted L‐Aspartic Acids Using Two C−N Lyases
N‐cycloalkyl‐substituted amino acids have wide‐ranging applications in pharma‐and
nutraceutical fields. Here we report the asymmetric synthesis of various N‐cycloalkyl …
nutraceutical fields. Here we report the asymmetric synthesis of various N‐cycloalkyl …