[HTML][HTML] ATM and ATR as therapeutic targets in cancer
AM Weber, AJ Ryan - Pharmacology & therapeutics, 2015 - Elsevier
In order to maintain genomic stability, cells have developed sophisticated signalling
pathways to enable DNA damage or DNA replication stress to be resolved. Key mediators of …
pathways to enable DNA damage or DNA replication stress to be resolved. Key mediators of …
Homologous recombination deficiency: cancer predispositions and treatment implications
MR Toh, J Ngeow - The oncologist, 2021 - academic.oup.com
Homologous recombination (HR) is a highly accurate DNA repair mechanism. Several HR
genes are established cancer susceptibility genes with clinically actionable pathogenic …
genes are established cancer susceptibility genes with clinically actionable pathogenic …
ATM and breast cancer susceptibility
ATM was originally identified by positional cloning as the gene that underlies the autosomal
recessive condition ataxia-telangiectasia. The encoded protein plays a central role in the …
recessive condition ataxia-telangiectasia. The encoded protein plays a central role in the …
ATM: main features, signaling pathways, and its diverse roles in DNA damage response, tumor suppression, and cancer development
ATM is among of the most critical initiators and coordinators of the DNA-damage response.
ATM canonical and non-canonical signaling pathways involve hundreds of downstream …
ATM canonical and non-canonical signaling pathways involve hundreds of downstream …
Identification of prognostic biomarkers and correlations with immune infiltrates among cGAS-STING in hepatocellular carcinoma
Z Qi, F Yan, D Chen, W **ng, Q Li, W Zeng… - Bioscience …, 2020 - portlandpress.com
The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway
induces innate immunity by activating the production of inflammatory cytokines and type I …
induces innate immunity by activating the production of inflammatory cytokines and type I …
Pathogenic ATM Mutations in Cancer and a Genetic Basis for Radiotherapeutic Efficacy
Background Radiation therapy is one of the most commonly used cancer therapeutics but
genetic determinants of clinical benefit are poorly characterized. Pathogenic germline …
genetic determinants of clinical benefit are poorly characterized. Pathogenic germline …
[HTML][HTML] Oxidative stress, mitochondrial abnormalities and antioxidant defense in Ataxia-telangiectasia, Bloom syndrome and Nijmegen breakage syndrome
M Maciejczyk, B Mikoluc, B Pietrucha… - Redox Biology, 2017 - Elsevier
Rare pleiotropic genetic disorders, Ataxia-telangiectasia (AT), Bloom syndrome (BS) and
Nijmegen breakage syndrome (NBS) are characterised by immunodeficiency, extreme …
Nijmegen breakage syndrome (NBS) are characterised by immunodeficiency, extreme …
ATM controls meiotic DNA double-strand break formation and recombination and affects synaptonemal complex organization in plants
MT Kurzbauer, MP Janisiw, LF Paulin… - The Plant …, 2021 - academic.oup.com
Meiosis is a specialized cell division that gives rise to genetically distinct gametic cells.
Meiosis relies on the tightly controlled formation of DNA double-strand breaks (DSBs) and …
Meiosis relies on the tightly controlled formation of DNA double-strand breaks (DSBs) and …
ATM kinase dead: From ataxia telangiectasia syndrome to cancer
Simple Summary Ataxia telangiectasia mutated (ATM) protein plays a pivotal role in the DNA-
damage response through activation of many different molecular targets. Mutations of the …
damage response through activation of many different molecular targets. Mutations of the …
The role of ATM mutations and 11q deletions in disease progression in chronic lymphocytic leukemia
T Stankovic, A Skowronska - Leukemia & lymphoma, 2014 - Taylor & Francis
ATM gene alteration is a frequent event in pathogenesis of chronic lymphocytic leukemia
(CLL) and occurs as monoallelic loss in the form of 11q23 deletion, with and without …
(CLL) and occurs as monoallelic loss in the form of 11q23 deletion, with and without …