The IL-17 family in diseases: from bench to bedside

L Huangfu, R Li, Y Huang, S Wang - Signal transduction and targeted …, 2023 - nature.com
Abstract The interleukin-17 (IL-17) family comprises six members (IL-17A–17F), and
recently, all of its related receptors have been discovered. IL-17 was first discovered …

[HTML][HTML] Lipocalin-2: Structure, function, distribution and role in metabolic disorders

S Al Jaberi, A Cohen, C D'Souza… - Biomedicine & …, 2021 - Elsevier
Abstract Lipocalin-2 (LCN-2) is a novel, 198 amino acid adipocytokine also referred to as
neutrophil gelatinase-associated lipocalin (NGAL). LCN-2 is a circulatory protein …

Adipokines, hepatokines and myokines: focus on their role and molecular mechanisms in adipose tissue inflammation

Y Ren, H Zhao, C Yin, X Lan, L Wu, X Du… - Frontiers in …, 2022 - frontiersin.org
Chronic low-grade inflammation in adipose tissue (AT) is a hallmark of obesity and
contributes to various metabolic disorders, such as type 2 diabetes and cardiovascular …

Circadian control of tumor immunosuppression affects efficacy of immune checkpoint blockade

BM Fortin, SM Pfeiffer, J Insua-Rodríguez… - Nature …, 2024 - nature.com
The circadian clock is a critical regulator of immunity, and this circadian control of immune
modulation has an essential function in host defense and tumor immunosurveillance. Here …

IL-17 receptor–based signaling and implications for disease

X Li, R Bechara, J Zhao, MJ McGeachy… - Nature immunology, 2019 - nature.com
IL-17 is a highly versatile pro-inflammatory cytokine crucial for a variety of processes,
including host defense, tissue repair, the pathogenesis of inflammatory disease and the …

Cell type-specific roles of NF-κB linking inflammation and thrombosis

M Mussbacher, M Salzmann, C Brostjan… - Frontiers in …, 2019 - frontiersin.org
The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …

Adipokines: new potential therapeutic target for obesity and metabolic, rheumatic, and cardiovascular diseases

L Recinella, G Orlando, C Ferrante… - Frontiers in …, 2020 - frontiersin.org
Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …

IL-17 signaling: the yin and the yang

N Amatya, AV Garg, SL Gaffen - Trends in immunology, 2017 - cell.com
Interleukin (IL)-17 is the founding member of a novel family of inflammatory cytokines. While
the proinflammatory properties of IL-17 are key to its host-protective capacity, unrestrained IL …

Interleukin 17 is a chief orchestrator of immunity

M Veldhoen - Nature immunology, 2017 - nature.com
Increased understanding of the biology of interleukin 17 (IL-17) has revealed that this
cytokine is a central player in immunity at the sites most exposed to microorganisms …

The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing

SL Gaffen, R Jain, AV Garg, DJ Cua - Nature reviews immunology, 2014 - nature.com
Following the discovery of T helper 17 (TH17) cells, the past decade has witnessed a major
revision of the TH subset paradigm and substantial progress has been made in deciphering …