Minor cannabinoids: Biosynthesis, molecular pharmacology and potential therapeutic uses

KB Walsh, AE McKinney, AE Holmes - Frontiers in pharmacology, 2021 - frontiersin.org
The medicinal use of Cannabis sativa L. can be traced back thousands of years to ancient
China and Egypt. While marijuana has recently shown promise in managing chronic pain …

Cannabinoids as anticancer drugs: Current status of preclinical research

B Hinz, R Ramer - British journal of cancer, 2022 - nature.com
Drugs that target the endocannabinoid system are of interest as pharmacological options to
combat cancer and to improve the life quality of cancer patients. From this perspective …

Medical cannabis activity against inflammation: active compounds and modes of action

SM Anil, H Peeri, H Koltai - Frontiers in pharmacology, 2022 - frontiersin.org
Inflammation often develops from acute, chronic, or auto-inflammatory disorders that can
lead to compromised organ function. Cannabis (Cannabis sativa) has been used to treat …

Anti-microbial activity of phytocannabinoids and endocannabinoids in the light of their physiological and pathophysiological roles

RV Sionov, D Steinberg - Biomedicines, 2022 - mdpi.com
Antibiotic resistance has become an increasing challenge in the treatment of various
infectious diseases, especially those associated with biofilm formation on biotic and abiotic …

Effects of tetrahydrocannabinols on human oral cancer cell proliferation, apoptosis, autophagy, oxidative stress, and DNA damage

A Semlali, S Beji, I Ajala, M Rouabhia - Archives of Oral Biology, 2021 - Elsevier
Abstract Objective Cannabinoids, including delta-8-and delta-9-tetrahydrocannabinol (THC)
have a palliative care impact and may therefore be beneficial against cancer. The aim of this …

Cannabidiol in neurological and neoplastic diseases: Latest developments on the molecular mechanism of action

M Ożarowski, TM Karpiński, A Zielińska… - International journal of …, 2021 - mdpi.com
As the major nonpsychotropic constituent of Cannabis sativa, cannabidiol (CBD) is regarded
as one of the most promising therapeutic agents due to its proven effectiveness in clinical …

[HTML][HTML] Anti-Cancer Activity of Cannabis sativa Phytocannabinoids: Molecular Mechanisms and Potential in the Fight against Ovarian Cancer and Stem Cells

H Koltai, N Shalev - Cancers, 2022 - mdpi.com
Simple Summary Ovarian cancer is the most lethal gynecological malignancy. Cancer stem
cells have been implicated in tumor initiation, progression, and invasion, as well as tumor …

Anti-cancer properties of cannflavin A and potential synergistic effects with gemcitabine, cisplatin, and cannabinoids in bladder cancer

AM Tomko, EG Whynot, DJ Dupré - Journal of Cannabis Research, 2022 - Springer
Introduction Several studies have shown anti-tumor effects of components present in
cannabis in different models. Unfortunately, little is known about the potential anti-tumoral …

Cancer Initiation, Progression and Resistance: Are Phytocannabinoids from Cannabis sativa L. Promising Compounds?

E Nigro, M Formato, G Crescente, A Daniele - Molecules, 2021 - mdpi.com
Cannabis sativa L. is a source of over 150 active compounds known as phytocannabinoids
that are receiving renewed interest due to their diverse pharmacologic activities. Indeed …

Cannabidiol and other phytocannabinoids as cancer therapeutics

G Nahler - Pharmaceutical medicine, 2022 - Springer
Preclinical models provided ample evidence that cannabinoids are cytotoxic against cancer
cells. Among the best studied phytocannabinoids, cannabidiol (CBD) is most promising for …