Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

More than 200 genes annotated as Na+/H+ hydrogen exchangers (NHEs) currently reside in
bioinformation databases such as GenBank and Pfam. We performed detailed phylogenetic …

This review describes recent progress concerning the molecular aspects of the Na+/H+
exchanger. The Na+/H+ exchanger is an important regulator for intracellular pH, cell volume …

With a homologous gene region we successfully isolated a Na+/H+ antiporter gene from a
halophytic plant, Atriplex gmelini, and named it AgNHX1. The isolated cDNA is 2607 bp in …

Six full-length gene transcripts ZmNHX1-6 from Zea mays L. that were homologous to
tonoplast-associated Na+/H+ antiporter were identified. The deduced transcripts code 538 …

Mammalian Na+/H+ exchangers of the SLC9A family are widely expressed and involved in
numerous essential physiological processes. Their primary function is to mediate the 1: 1 …

Most cultivated lands are suffering from soil salinization, which is a global problem affecting
agricultural development and economy. High NaCl concentrations in the soil result in the …

The NHE1 isoform of the Na+/H+ exchanger is a ubiquitous plasma membrane protein that
regulates intracellular pH in mammalian cells. Site‐specific mutagenesis was used to …

The Na+/H+ exchanger is a ubiquitous, integral membrane protein involved in pH
regulation. It removes intracellular acid, exchanging a proton for an extracellular sodium ion …

Despite 30 years of study on Na+/H+ exchange, the molecular mechanisms of antiport
remain obscure. Most challenging, the identity of amino acids involved in binding …