Melatonin—A pleiotropic, orchestrating regulator molecule

R Hardeland, DP Cardinali, V Srinivasan… - Progress in …, 2011 - Elsevier
Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …

The role of melatonin in the cells of the innate immunity: a review

JR Calvo, C Gonzalez‐Yanes… - Journal of pineal …, 2013 - Wiley Online Library
Melatonin is the major secretory product synthesized and secreted by the pineal gland and
shows both a wide distribution within phylogenetically distant organisms from bacteria to …

Melatonin in food allergy: Mechanism and potential therapy

H Wang, Y Yan, I Hung, C Liu, J Yin… - Journal of Pineal …, 2023 - Wiley Online Library
Food allergy affects more than 500 million people in the world, and its prevalence is
increasing at an alarming rate causing serious public health concerns; however, prevention …

Melatonin signaling in T cells: Functions and applications

W Ren, G Liu, S Chen, J Yin, J Wang… - Journal of pineal …, 2017 - Wiley Online Library
Melatonin affects a variety of physiological processes including circadian rhythms, cellular
redox status, and immune function. Importantly, melatonin significantly influences T‐cell …

Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms

R Hardeland - Journal of pineal research, 2013 - Wiley Online Library
The classic theories of aging such as the free radical theory, including its mitochondria‐
related versions, have largely focused on a few specific processes of senescence …

Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: a therapeutic target to reduce intestinal inflammation

N Ma, J Zhang, RJ Reiter, X Ma - Medicinal Research Reviews, 2020 - Wiley Online Library
Nowadays, melatonin, previously considered only as a pharmaceutical product for rhythm
regulation and sleep aiding, has shown its potential as a co‐adjuvant treatment in intestinal …

Melatonin, immune function and aging

V Srinivasan, GJM Maestroni, DP Cardinali… - Immunity & …, 2005 - Springer
Aging is associated with a decline in immune function (immunosenescence), a situation
known to correlate with increased incidence of cancer, infectious and degenerative …

The role of melatonin in immuno‐enhancement: potential application in cancer

SC Miller, PSR Pandi, AI Esquifino… - International journal …, 2006 - Wiley Online Library
Melatonin, a neurohormone produced mainly by the pineal gland, is a modulator of
haemopoiesis and of immune cell production and function, both in vivo and in vitro …

Role of melatonin in the inflammatory process and its therapeutic potential

L Carrascal, P Nunez-Abades, A Ayala… - Current …, 2018 - ingentaconnect.com
Melatonin is an indolamine synthesized and secreted by the pineal gland along with other
extrapineal sources including immune system cells, the brain, skin and the gastrointestinal …

Cadmium activates the innate immune system through the AIM2 inflammasome

L Zhao, M Liao, L Li, L Chen, T Zhang, R Li - Chemico-Biological …, 2024 - Elsevier
Cadmium (Cd) is a widely used heavy metal and has recently been recognized as a
possible source of human toxicity due to its ability to accumulate in organs. Accumulation of …