Gut-liver-brain axis is a three-way highway of information interaction system among the
gastrointestinal tract, liver, and nervous systems. In the past few decades, breakthrough …

Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …

Nowadays, one of the leading causes of death in humans is cancer, which is still on the rise
globally and is in great need of intense study on the pathogenic mechanism and effective …

Lactic acid, traditionally considered as a metabolic waste product arising from glycolysis,
has undergone a resurgence in scientific interest since the discovery of the Warburg effect in …

The methylation of histone H3 at lysine 36 (H3K36me) is essential for maintaining genomic
stability. Indeed, this methylation mark is essential for proper transcription, recombination …

DNA methylation is one of the most important epigenetic mechanisms that governing
regulation of gene expression, aberrant DNA methylation patterns are strongly associated …

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

During tumor development, promoter CpG islands that are normally silenced by Polycomb
repressive complexes (PRCs) become DNA-hypermethylated. The molecular mechanism by …

Drug resistance in hepatocellular carcinoma has posed significant obstacles to effective
treatment. Recent evidence indicates that, in addition to traditional gene mutations …

The interplay between histone modifications and DNA methylation drives the establishment
and maintenance of the cellular epigenomic landscape, but it remains challenging to …