Organ-on-a-chip devices have enabled major breakthroughs in biomedical research, but
they have yet to be successfully translated to the pharmaceutical industry. Traditional …

Technological advances in microfabrication techniques in combination with organotypic cell
and tissue models have enabled the realization of microphysiological systems capable of …

Regulation of cosmetic testing and poor predictivity of preclinical drug studies has spurred
efforts to develop new methods for systemic toxicity. Current in vitro assays do not fully …

A pumpless, reconfigurable, multi-organ–on–a–chip system containing recirculating serum-
free medium can be used to predict preclinical on-target efficacy, metabolic conversion, and …

Functional human-on-a-chip systems hold great promise to enable quantitative translation to
in vivo outcomes. Here, we explored this concept using a pumpless heart only and heart …

A functional, human, multiorgan, pumpless, immune system‐on‐a‐chip featuring
recirculating THP‐1 immune cells with cardiomyocytes, skeletal muscle, and liver in …

The goal of human‐on‐a‐chip systems is to capture multiorgan complexity and predict the
human response to compounds within physiologically relevant platforms. The generation …

The physical connection between motoneurons and skeletal muscle targets is responsible
for the creation of neuromuscular junctions (NMJs), which allow electrical signals to be …

Recent findings suggest a pathologic role of skeletal muscle in amyotrophic lateral sclerosis
(ALS) onset and progression. However, the exact mechanism by which this occurs remains …

In vitro generation of functional neuromuscular junctions (NMJs) utilizing the same induced
pluripotent stem cell (iPSC) source for muscle and motoneurons would be of great value for …