Curved membranes are key features of intracellular organelles, and their generation
involves dynamic protein complexes. Here we describe the fundamental mechanisms such …

Clathrin-mediated endocytosis enables selective uptake of molecules into cells in response
to changing cellular needs. It occurs through assembly of coat components around the …

Cryo-electron tomography (cryoET) provides sub-nanometer protein structure within the
dense cellular environment. Existing sample preparation methods are insufficient at …

Actin assembly provides force for a multitude of cellular processes. Compared to actin-
assembly-based force production during cell migration, relatively little is understood about …

Eukaryotic cells use clathrin-mediated endocytosis to take up a large range of extracellular
cargo. During endocytosis, a clathrin coat forms on the plasma membrane, but it remains …

Clathrin-mediated endocytosis (CME) requires energy input from actin polymerization in
mechanically challenging conditions. The roles of actin in CME are poorly understood due to …

Clathrin-mediated endocytosis (CME) is the main mechanism by which mammalian cells
control their cell surface proteome. Proper operation of the pivotal CME cargo adaptor AP2 …

Reticular adhesions (RAs) consist of integrin αvβ5 and harbor flat clathrin lattices (FCLs),
long-lasting structures with similar molecular composition as clathrin-mediated endocytosis …

During clathrin-mediated endocytosis (CME), flat plasma membrane is remodeled to
produce nanometer-scale vesicles. The mechanisms underlying this remodeling are not …

Caveolae are small coated plasma membrane invaginations with diverse functions.
Caveolae undergo curvature changes. Yet, it is unclear which proteins regulate this process …