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Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models
The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …
Neuropathology and biochemistry of Aβ and its aggregates in Alzheimer's disease
Alzheimer's disease (AD) is characterized by β-amyloid plaques and intraneuronal τ
aggregation usually associated with cerebral amyloid angiopathy (CAA). Both β-amyloid …
aggregation usually associated with cerebral amyloid angiopathy (CAA). Both β-amyloid …
The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model …
AM Sabogal-Guáqueta, JI Muñoz-Manco… - …, 2015 - Elsevier
Alzheimer's disease (AD) is the most common senile dementia in the world. Although
important progress has been made in understanding the pathogenesis of AD, current …
important progress has been made in understanding the pathogenesis of AD, current …
Protein restriction slows the development and progression of pathology in a mouse model of Alzheimer's disease
R Babygirija, MM Sonsalla, J Mill, I James… - Nature …, 2024 - nature.com
Dietary protein is a critical regulator of metabolic health and aging. Low protein diets are
associated with healthy aging in humans, and dietary protein restriction extends the lifespan …
associated with healthy aging in humans, and dietary protein restriction extends the lifespan …
IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer's disease
Neuroinflammation in patients with Alzheimer's disease (AD) and related mouse models has
been recognized for decades, but the contribution of the recently described meningeal …
been recognized for decades, but the contribution of the recently described meningeal …
Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice
V Rhein, X Song, A Wiesner, LM Ittner… - Proceedings of the …, 2009 - pnas.org
Alzheimer's disease (AD) is characterized by amyloid-beta (Aβ)-containing plaques,
neurofibrillary tangles, and neuron and synapse loss. Tangle formation has been …
neurofibrillary tangles, and neuron and synapse loss. Tangle formation has been …
A non-transgenic mouse model (icv-STZ mouse) of Alzheimer's disease: similarities to and differences from the transgenic model (3xTg-AD mouse)
Y Chen, Z Liang, J Blanchard, CL Dai, S Sun… - Molecular …, 2013 - Springer
Alzheimer's disease (AD) can be divided into sporadic AD (SAD) and familial AD (FAD).
Most AD cases are sporadic and result from multiple etiologic factors, including …
Most AD cases are sporadic and result from multiple etiologic factors, including …
[HTML][HTML] The endoplasmic reticulum stress and unfolded protein response in Alzheimer's disease: a calcium dyshomeostasis perspective
Protein misfolding is prominent in early cellular pathology of Alzheimer's disease (AD),
implicating pathophysiological significance of endoplasmic reticulum stress/unfolded protein …
implicating pathophysiological significance of endoplasmic reticulum stress/unfolded protein …
Rodent models for Alzheimer's disease drug discovery
Introduction: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by
memory loss and personality changes, leading to dementia. Histopathological hallmarks are …
memory loss and personality changes, leading to dementia. Histopathological hallmarks are …
Exosomes in pathogenesis, diagnosis, and treatment of Alzheimer's disease
L Jiang, H Dong, H Cao, X Ji… - … medical journal of …, 2019 - pmc.ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the
accumulation of β-amyloid peptide 1-42 and phosphorylation of tau protein in the brain …
accumulation of β-amyloid peptide 1-42 and phosphorylation of tau protein in the brain …