A striking change has happened in the field of immunology whereby specific metabolic
processes have been shown to be a critical determinant of immune cell activation. Multiple …

Following detection of bacteria, macrophages switch their metabolism from oxidative
respiration through the tricarboxylic acid cycle to high-rate aerobic glycolysis. This …

Exposure of lipopolysaccharide triggers macrophage pro-inflammatory polarization
accompanied by metabolic reprogramming, characterized by elevated aerobic glycolysis …

Nitric Oxide (NO) is a soluble endogenous gas with various biological functions like
signaling, and working as an effector molecule or metabolic regulator. In response to …

Macrophage immunometabolism, the changes in intracellular metabolic pathways that alter
the function of these highly plastic cells, has been the subject of intense interest in the past …

Staphylococcus aureus is a prominent human pathogen that readily adapts to host immune
defenses. Here, we show that, in contrast to Gram-negative pathogens, S. aureus induces a …

The multifunctional protein, voltage-dependent anion channel 1 (VDAC1), is located on the
mitochondrial outer membrane. It is a pivotal protein that maintains mitochondrial function to …

The tumor microenvironment (TME) contains a complex cellular ecosystem where cancer,
stromal, vascular, and immune cells interact. Macrophages and regulatory T cells (Tregs) …

With advances in immunometabolic studies, more and more evidence has shown that
metabolic changes profoundly affect the immune function of macrophages. The tricarboxylic …

Macrophages are versatile immune cells associated with various diseases, and their
phenotypes and functions change on the basis of the surrounding environments …