[HTML][HTML] Organs-on-chips technologies–A guide from disease models to opportunities for drug development
Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …
human physiopathology with striking discrepancies in estimating drug efficacy and side …
[HTML][HTML] Tumor-on-chip modeling of organ-specific cancer and metastasis
Every year, cancer claims millions of lives around the globe. Unfortunately, model systems
that accurately mimic human oncology–a requirement for the development of more effective …
that accurately mimic human oncology–a requirement for the development of more effective …
Metabolic reprogramming of colorectal cancer cells and the microenvironment: implication for therapy
M Nenkov, Y Ma, N Gaßler, Y Chen - International journal of molecular …, 2021 - mdpi.com
Colorectal carcinoma (CRC) is one of the most frequently diagnosed carcinomas and one of
the leading causes of cancer-related death worldwide. Metabolic reprogramming, a hallmark …
the leading causes of cancer-related death worldwide. Metabolic reprogramming, a hallmark …
A one-stop microfluidic-based lung cancer organoid culture platform for testing drug sensitivity
Microfluidic devices as translational research tools provide a potential alternative to animal
experiments due to their ability to mimic physiological parameters. Several approaches that …
experiments due to their ability to mimic physiological parameters. Several approaches that …
Microvascularized tumor organoids-on-chips: advancing preclinical drug screening with pathophysiological relevance
Recent developments of organoids engineering and organ-on-a-chip microfluidic
technologies have enabled the recapitulation of the major functions and architectures of …
technologies have enabled the recapitulation of the major functions and architectures of …
Mutant P53 in the formation and progression of the tumor microenvironment: friend or foe
TP53 is the most frequently mutated gene in human cancer. It encodes the tumor suppressor
protein p53, which suppresses tumorigenesis by acting as a critical transcription factor that …
protein p53, which suppresses tumorigenesis by acting as a critical transcription factor that …
Heterotypic tumor spheroids: a platform for nanomedicine evaluation
Nanomedicine has emerged as a promising therapeutic approach, but its translation to the
clinic has been hindered by the lack of cellular models to anticipate how tumor cells will …
clinic has been hindered by the lack of cellular models to anticipate how tumor cells will …
On-chip anticancer drug screening–Recent progress in microfluidic platforms to address challenges in chemotherapy
There is an increasing need for advanced and inexpensive preclinical models to accelerate
the development of anticancer drugs. While costly animal models fail to predict human …
the development of anticancer drugs. While costly animal models fail to predict human …
Cancer-on-chip: a 3D model for the study of the tumor microenvironment
E Cauli, MA Polidoro, S Marzorati, C Bernardi… - Journal of Biological …, 2023 - Springer
The approval of anticancer therapeutic strategies is still slowed down by the lack of models
able to faithfully reproduce in vivo cancer physiology. On one hand, the conventional in vitro …
able to faithfully reproduce in vivo cancer physiology. On one hand, the conventional in vitro …
Copper-induced injectable hydrogel with nitric oxide for enhanced immunotherapy by amplifying immunogenic cell death and regulating cancer associated fibroblasts
S Shen, Z Zhang, H Huang, J Yang, X Tao… - Biomaterials …, 2023 - spj.science.org
Background Immunogenic cell death (ICD) induced by different cancer treatments has been
widely evaluated to recruit immune cells and trigger the specific antitumor immunity …
widely evaluated to recruit immune cells and trigger the specific antitumor immunity …