The human CNS follows a pattern of development typical of all mammals, but certain
neurodevelopmental features are highly derived. Building the human CNS requires the …

There has been much progress in genomics in the ten years since a draft sequence of the
human genome was published. Opportunities for understanding health and disease are now …

Background Multiple genome alignment remains a challenging problem. Effects of
recombination including rearrangement, segmental duplication, gain, and loss can create a …

Methods for detecting nucleotide substitution rates that are faster or slower than expected
under neutral drift are widely used to identify candidate functional elements in genomic …

Computational efforts to identify functional elements within genomes leverage comparative
sequence information by looking for regions that exhibit evidence of selective constraint …

A major yet unresolved quest in decoding the human genome is the identification of the
regulatory sequences that control the spatial and temporal expression of genes. Distant …

We have developed a comprehensive gene orientated phylogenetic resource,
EnsemblCompara GeneTrees, based on a computational pipeline to handle clustering …

The success of genome-wide association (GWA) studies for the detection of sequence
variation affecting complex traits in human has spurred interest in the use of large-scale high …

Regulatory T (Treg) cells, whose differentiation and function are controlled by X
chromosome-encoded transcription factor Foxp3, are generated in the thymus (tTreg) and …

Transcription factors (TFs) direct gene expression by binding to DNA regulatory regions. To
explore the evolution of gene regulation, we used chromatin immunoprecipitation with high …