Nonlinear and stochastic dynamics in the heart
In a normal human life span, the heart beats about 2–3 billion times. Under diseased
conditions, a heart may lose its normal rhythm and degenerate suddenly into much faster …
conditions, a heart may lose its normal rhythm and degenerate suddenly into much faster …
Unified form language: A domain-specific language for weak formulations of partial differential equations
We present the Unified Form Language (UFL), which is a domain-specific language for
representing weak formulations of partial differential equations with a view to numerical …
representing weak formulations of partial differential equations with a view to numerical …
Multi-scale computational modeling of spatial calcium handling from nanodomain to whole-heart: Overview and perspectives
Regulation of intracellular calcium is a critical component of cardiac electrophysiology and
excitation-contraction coupling. The calcium spark, the fundamental element of the …
excitation-contraction coupling. The calcium spark, the fundamental element of the …
[BUKU][B] Models of calcium signalling
The interactions between mathematics and physiology have a long and illustrious history, of
which the study of calcium signalling is but a small chapter. Nevertheless, for those involved …
which the study of calcium signalling is but a small chapter. Nevertheless, for those involved …
Ryanodine receptor dispersion disrupts Ca2+ release in failing cardiac myocytes
Reduced cardiac contractility during heart failure (HF) is linked to impaired Ca2+ release
from Ryanodine Receptors (RyRs). We investigated whether this deficit can be traced to …
from Ryanodine Receptors (RyRs). We investigated whether this deficit can be traced to …
Superresolution modeling of calcium release in the heart
Stable calcium-induced calcium release (CICR) is critical for maintaining normal cellular
contraction during cardiac excitation-contraction coupling. The fundamental element of …
contraction during cardiac excitation-contraction coupling. The fundamental element of …
Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure
Ryanodine receptors (RyRs) exhibit dynamic arrangements in cardiomyocytes, and we
previously showed that 'dispersion'of RyR clusters disrupts Ca 2+ homeostasis during heart …
previously showed that 'dispersion'of RyR clusters disrupts Ca 2+ homeostasis during heart …
Calcium and IP3 dynamics in cardiac myocytes: experimental and computational perspectives and approaches
F Hohendanner, AD McCulloch, LA Blatter… - Frontiers in …, 2014 - frontiersin.org
Calcium plays a crucial role in excitation-contraction coupling (ECC), but it is also a pivotal
second messenger activating Ca2+-dependent transcription factors in a process termed …
second messenger activating Ca2+-dependent transcription factors in a process termed …
Improved computational identification of drug response using optical measurements of human stem cell derived cardiomyocytes in microphysiological systems
Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) hold great
potential for drug screening applications. However, their usefulness is limited by the relative …
potential for drug screening applications. However, their usefulness is limited by the relative …
Multi-scale modeling of the cardiovascular system: disease development, progression, and clinical intervention
Cardiovascular diseases (CVDs) are the leading cause of death in the western world. With
the current development of clinical diagnostics to more accurately measure the extent and …
the current development of clinical diagnostics to more accurately measure the extent and …