The develo** brain is sensitive to a variety of insults. Epidemiological studies have
identified prenatal exposure to infection as a risk factor for a range of neurological disorders …

MeCP2 is a reader of the DNA methylome that occupies a large proportion of the genome
due to its high abundance and the frequency of its target sites. It has been the subject of …

Through epigenetic modifications, specific long-term phenotypic consequences can arise
from environmental influence on slowly evolving genomic DNA. Heritable epigenetic …

Epigenetic mechanisms regulate cell differentiation during embryonic development and also
serve as important interfaces between genes and the environment in adulthood …

Methyl-CpG binding protein 1 (MBD1) regulates gene expression via a DNA methylation-
mediated epigenetic mechanism. We have previously demonstrated that MBD1 deficiency …

Oxidative stress and abnormal DNA methylation have been implicated in the
pathophysiology of autism. We investigated the dynamics of an integrated metabolic …

Neurodevelopmental diseases (NDDs), such as autism spectrum disorders, epilepsy, and
schizophrenia, are characterized by diverse facets of neurological and psychiatric …

OBJECTIVE: Current research suggests that the causes of autism spectrum disorders (ASD)
are multifactorial and include both genetic and environmental factors. Several lines of …

The identification of neural stem cells (NSCs) and their contribution to continuous
neurogenesis has shown that the hippocampus and olfactory bulb are plastic. Brain …

Persons with neurodevelopmental disorders or autism spectrum disorder (ASD) often harbor
chromosomal microdeletions, yet the individual genetic contributors within these regions …