Plastics pollution is causing an environmental crisis, prompting the development of new
approaches for recycling, and upcycling. Here, we review challenges and opportunities in …

Alkoxy radicals are highly reactive species that have long been recognized as versatile
intermediates in organic synthesis. However, their development has long been impeded due …

Conspectus Carbon dioxide (CO2) is recognized as a greenhouse gas and a common
waste product. Simultaneously, it serves as an advantageous and commercially available …

When searching for the ideal molecule to fill a particular functional role (for example, a
medicine), the difference between success and failure can often come down to a single …

Late-stage functionalization (LSF) introduces functional group or structural modification at
the final stage of the synthesis of natural products, drugs, and complex compounds. It is …

This article reviews synthetic transformations involving cleavage of a carbon–carbon bond of
a four-membered ring, with a particular focus on the examples reported during the period …

Transition-metal-catalyzed cross-coupling reactions have been well-established as
indispensable tools in modern organic synthesis. One of the major research goals in cross …

Conspectus Bridged and fused rings are commonly found in biologically important
molecules. Current tactics to construct these ring systems are primarily based on stepwise …

Carbon-carbon bond cleavage mechanisms play a key role in the selective deconstruction
of alkanes and polyolefins. Here, we show that the product distribution, which encompasses …

Conspectus C–C single bonds are ubiquitous in organic compounds. The activation and
subsequent functionalization of C–C single bonds provide a unique opportunity to …