The pathophysiology of glaucoma is complex, multifactorial and not completely understood.
Elevated intraocular pressure (IOP) and/or impaired retinal blood flow may cause initial optic …

Microglia, the immunocompetent cells of the central nervous system (CNS), act as
neuropathology sensors and are neuroprotective under physiological conditions. Microglia …

Summary The apolipoprotein E4 (APOE4) allele is associated with an increased risk of
Alzheimer disease and a decreased risk of glaucoma, but the underlying mechanisms …

Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …

The eye is regarded as an immune privileged site. Since the presence of a vasculature
would impair vision, the vasculature of the eye is located outside of the central light path. As …

Microglia, the primary resident immune cell type, constitute a key population of glia in the
retina. Recent evidence indicates that microglia play significant functional roles in the retina …

Nicotinamide adenine dinucleotide (NAD) is a REDOX cofactor and metabolite essential for
neuronal survival. Glaucoma is a common neurodegenerative disease in which neuronal …

Resident microglial cells can be regarded as the immunological watchdogs of the brain and
the retina. They are active sensors of their neuronal microenvironment and rapidly respond …

Mounting evidence suggests neuroinflammation is a key process in glaucoma, yet the
precise roles are not known. Understanding these complex processes, which may also be a …

Glaucoma is a complex neurodegenerative disease with many clinical subtypes. Some of its
rare forms include pigmentary glaucoma, uveitic glaucoma and congenital glaucoma. While …