Abstract Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate
acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably …

Tumor cellular metabolism exhibits distinguishing features that collectively enhance
biomass synthesis while maintaining redox balance and cellular homeostasis. These …

Protein-restricted diets promote health and longevity in many species. While the precise
components of a protein-restricted diet that mediate the beneficial effects to longevity have …

Protein lysine acetylation is an important posttranslational modification that regulates
numerous biological processes. Targeting lysine acetylation regulatory factors, such as …

Amino acid metabolism plays a pivotal role in tumor microenvironment, influencing various
aspects of cancer progression. The metabolic reprogramming of amino acids in tumor cells …

The tumorigenic role and underlying mechanisms of lipid accumulation, commonly observed
in many cancers, remain insufficiently understood. In this study, we identified an AMP …

Short-chain enoyl-CoA hydratase 1 (ECHS1) deficiency plays a role in cardiomyopathy.
Whether ECHS1 deficiency causes or is only associated with cardiomyopathy remains …

Abstract Isocitrate dehydrogenase (IDH) 1 and 2, as essential enzymes in energy
metabolism, contribute to the survival and drug resistance of a variety of solid tumors …

The homeostasis of mitochondrial functional state is intimately in relation with SIRT3
(sirtuin3). SIRT3, the deacetylase mainly anchored in mitochondria, acts as a modulator of …

Aging is a key risk factor for angiogenic dysfunction and cardiovascular diseases, including
heart failure, hypertension, atherosclerosis, diabetes, and stroke. Members of the NAD+ …