Background Genetic influences are ubiquitous as virtually all phenotypes and most
exposures typically classified as environmental have been found to be heritable. A …

BackgroundPoor mental health has consistently been associated with substance use
(smoking, alcohol drinking, cannabis use, and consumption of caffeinated drinks). To …

Suicide is a global public health challenge, yet considerable uncertainty remains regarding
the associations of both behaviour-related and physiological factors with suicide attempts …

Suicidal ideation, suicide attempt (SA) and suicide are significantly heritable phenotypes.
However, the extent to which these phenotypes share genetic architecture is unclear. This …

Observational studies have linked cannabis use to an array of negative outcomes, including
psychiatric symptoms, cognitive impairment, and educational and occupational …

Suicide is a multifaceted and poorly understood clinical outcome, and there is an urgent
need to advance research on its phenomenology and etiology. Epidemiological studies …

Background Early sexual intercourse and a greater number of sexual partners have been
proved associated with depression. However, the causality of these associations is not clear …

Substance use disorders represent a significant public health concern with considerable
socioeconomic implications worldwide. Twin and family-based studies have long …

Background The predictive relationship between mild-to-moderate alcohol consumption and
the risk of incident atrial fibrillation (AF) remains controversial. Objective We investigated …

Background A priority for health services is to reduce self-harm in young people. Predicting
self-harm is challenging due to their rarity and complexity, however this does not preclude …