Neurological disorders are the leading cause of disability and the second largest cause of
death worldwide. Despite significant research efforts, neurology remains one of the most …

The widespread adoption of microfluidic devices among the neuroscience and neurobiology
communities has enabled addressing a broad range of questions at the molecular, cellular …

Abstract Organ-on-a-chip (OOC, organ chip) technology can closely simulate the human
microenvironment, synthesize organ-like functional units on a fluidic chip substrate, and …

The human brain is a complex organ composed of many different types of cells
interconnected to create an organized system able to efficiently process information …

Technologies for axon guidance for in vitro disease models and bottom up investigations are
increasingly being used in neuroscience research. One of the most prevalent patterning …

Neurofibrillary tangles, formed of misfolded, hyperphosphorylated tau protein, are a
pathological hallmark of several neurodegenerations, including Alzheimer's disease. Tau …

Objective. Microfluidic devices interfaced with microelectrode arrays have in recent years
emerged as powerful platforms for studying and manipulating in vitro neuronal networks at …

Engineered biological neural networks are indispensable models for investigation of neural
function and dysfunction from the subcellular to the network level. Notably, advanced …

Tau aggregation and hyperphosphorylation is a key neuropathological hallmark of
Alzheimer's disease (AD), and the temporospatial spread of Tau observed during clinical …

Understanding the retinogeniculate pathway in vitro can offer insights into its development
and potential for future therapeutic applications. This study presents a Polydimethylsiloxane …