Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …

Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

Abstract Information storage and retrieval is essential for all life. In biology, information is
primarily stored in two distinct ways: the genome, comprising nucleic acids, acts as a …

Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …

Aging is a biological phenomenon in which the structure and function of organisms declining
with the increasing of age. It has become a major risk factor of human diseases, including …

Dietary restriction (DR) decreases body weight, improves health, and extends lifespan. DR
can be achieved by controlling how much and/or when food is provided, as well as by …

Aging is considered the deterioration of physiological functions along with an increased
mortality rate. This scientific review focuses on the central importance of genomic instability …

The increase in life expectancy has boosted the incidence of age-related pathologies
beyond social and economic sustainability. Consequently, there is an urgent need for …

Sirtuin is an essential factor that delays cellular senescence and extends the organismal
lifespan through the regulation of diverse cellular processes. Suppression of cellular …