Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection
Neutralizing antibodies are known to have a crucial role in protecting against SARS-CoV-2
infection and have been suggested to be a useful correlate of protection for vaccine clinical …
infection and have been suggested to be a useful correlate of protection for vaccine clinical …
[HTML][HTML] mRNA vaccines for COVID-19: what, why and how
Abstract The Coronavirus disease-19 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2), has impacted human lives in the most …
respiratory syndrome coronavirus-2 (SARS-CoV-2), has impacted human lives in the most …
A perspective on potential antibody-dependent enhancement of SARS-CoV-2
Antibody-dependent enhancement (ADE) of disease is a general concern for the
development of vaccines and antibody therapies because the mechanisms that underlie …
development of vaccines and antibody therapies because the mechanisms that underlie …
In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies
Summary SARS-CoV-2-neutralizing antibodies (NAbs) protect against COVID-19. A concern
regarding SARS-CoV-2 antibodies is whether they mediate disease enhancement. Here, we …
regarding SARS-CoV-2 antibodies is whether they mediate disease enhancement. Here, we …
IgG4-related disease: an update on pathophysiology and implications for clinical care
CA Perugino, JH Stone - Nature Reviews Rheumatology, 2020 - nature.com
Abstract IgG4-related disease (IgG4-RD) has only existed as a unique disease entity since
2003, yet remarkable progress has already been achieved in describing the essential …
2003, yet remarkable progress has already been achieved in describing the essential …
Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy
Neutralizing antibodies (NAbs) are effective in treating COVID-19, but the mechanism of
immune protection is not fully understood. Here, we applied live bioluminescence imaging …
immune protection is not fully understood. Here, we applied live bioluminescence imaging …
A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection
Emerging evidence indicates that both neutralizing and Fc-mediated effector functions of
antibodies contribute to protection against SARS-CoV-2. It is unclear whether Fc-effector …
antibodies contribute to protection against SARS-CoV-2. It is unclear whether Fc-effector …
Dual targeted extracellular vesicles regulate oncogenic genes in advanced pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) tumours carry multiple gene mutations and
respond poorly to treatments. There is currently an unmet need for drug carriers that can …
respond poorly to treatments. There is currently an unmet need for drug carriers that can …
Decoding the human immunoglobulin G-glycan repertoire reveals a spectrum of Fc-receptor-and complement-mediated-effector activities
Glycosylation of the immunoglobulin G (IgG)-Fc tail is required for binding to Fc-gamma
receptors (FcγRs) and complement-component C1q. A variety of IgG1-glycoforms is …
receptors (FcγRs) and complement-component C1q. A variety of IgG1-glycoforms is …
An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma
Oncolytic herpes simplex virus-1 is capable of lysing tumor cells while alerting the immune
system. CD47, in collaboration with SIRPα, represents an important immune checkpoint to …
system. CD47, in collaboration with SIRPα, represents an important immune checkpoint to …