The wide variety of clinical manifestations of the genetic syndrome neurofibromatosis type 1
(NF1) are driven by overactivation of the RAS pathway. Mitogen-activated protein kinase …

Summary Background Neurofibromatosis type 1 (NF1) is a multisystem genetic disorder,
predisposing development of benign and malignant tumours. Given the oncogenic potential …

Objective This meta-analysis aimed to robustly estimate differences in attention-
deficit/hyperactivity disorder (ADHD) symptoms between children and adolescents with and …

ABSTRACT Introduction Neurofibromatosis type 1 (NF1) is a rare neurogenetic disorder
characterized by multiple organ system involvement and a predisposition to benign and …

Background To examine the impact of executive function disorders on health-related quality
of life (QoL) in children with neurofibromatosis type 1 (NF1), we conducted a prospective …

Abstract Purpose An estimated 5–11% of patients with neurofibromatosis type 1 (NF1)
harbour NF1 microdeletions encompassing the NF1 gene and its flanking regions. The …

Abstract Objectives Neurofibromatosis type 1 (NF1) is a genetic cancer predisposition
syndrome that can impact multiple organ systems and is associated with plexiform …

Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent neurodevelopmental
disorder resulting from the interaction between genetic and environmental risk factors. It is …

Results Meta-analyses revealed significantly larger whole brain volume, gray and white
matter volumes, and subcortical volumes in NF1 compared to controls. FXS was associated …

Patients with neurofibromatosis type 1 (NF1) and type 1 NF1 deletions often exhibit more
severe clinical manifestations than patients with intragenic NF1 gene mutations, including …