Aging is defined as a progressive time‐related accumulation of changes responsible for or
at least involved in the increased susceptibility to disease and death. The brain seems to be …

Neurodegenerative disorders affect around one billion people worldwide. They can arise
from a combination of genomic, epigenomic, metabolic, and environmental factors. Aging is …

Alzheimer's disease (AD) is the most common form of dementia affecting people mainly in
their sixth decade of life and at a higher age. It is an extensively studied neurodegenerative …

Mitochondria play an essential role in the generation of steroid hormones including the
female sex hormones. These hormones are, in turn, able to modulate mitochondrial …

Abnormal tau protein aggregation in the brain is a hallmark of tauopathies, such as
frontotemporal lobar degeneration and Alzheimer's disease. Substantial evidence has been …

The mitochondria have a fundamental role in both cellular energy supply and oxidative
stress regulation and are target of the effects of sex steroids, particularly the neuroprotective …

Tauopathy is a collective term for neurodegenerative diseases associated with pathological
modifications of tau protein. Tau modifications are mediated by many factors. Recently …

Translocator protein 18 kDa (TSPO) is located in the mitochondrial outer membrane and
plays an important role in steroidogenesis and cell survival. In the central nervous system …

Gonadal steroid hormones are neurotrophic and neuroprotective. These effects are
modulated by local metabolism of the hormones within the brain. Such control is necessary …

The develo** and adult brain is a target organ for the vast majority of hormones produced
by the body, which are able to cross the blood–brain barrier and bind to their specific …