Opioid use in the United States has steadily risen since the 1990s, along with staggering
increases in addiction and overdose fatalities. With this surge in prescription and illicit opioid …

Positron emission tomography (PET) is a molecular imaging modality that enables in vivo
exploration of metabolic processes and especially the pharmacology of neuroreceptors. G …

Animal studies indicate that the kappa-opioid receptor/dynorphin system plays an important
role in cocaine binges and stress-induced relapse. Our goal was to investigate changes in …

The discovery of endogenous peptide ligands for morphine binding sites occurred in parallel
with the identification of three subclasses of opioid receptor (OR), traditionally designated as …

Endogenous kappa opioids mediate pathological responses to stress in animal models.
However, the relationship of the kappa opioid receptor (KOR) to life stress and to …

Early brain injury (EBI) refers to the direct injury to the brain during the first 72 h after
subarachnoid hemorrhage (SAH), which is one of the major causes for the poor clinical …

Kappa opioid receptor (KOR) modulation has been pursued in many conceptual frameworks
for the treatment of human pain, depression, and anxiety. As such, several imaging tools …

Molecular imaging, which allows the real-time visualization, characterization and
measurement of biological processes, is becoming increasingly used in neuroscience …

PET has deep roots in neuroscience stemming from its first application in brain tumor and
brain metabolism imaging. PET emerged over the past few decades and continues to play a …

Abstract κ‐Opioid receptors (KORs) play a predominant role in pain alleviation, itching skin
diseases, depression and neurodegenerative disorders such as multiple sclerosis …