Organismal aging is inherently connected to the aging of its constituent cells and systems.
Reducing the biological age of the organism may be assisted by reducing the age of its cells …

DNA methylation marks have recently been used to build models known as epigenetic
clocks, which predict calendar age. As methylation of cytosine promotes C-to-T mutations …

Age-related changes in DNA methylation (DNAm) form the basis of the most robust
predictors of age—epigenetic clocks—but a clear mechanistic understanding of exactly …

Many Mendelian developmental disorders caused by coding variants in epigenetic
regulators have now been discovered. Epigenetic regulators are broadly expressed, and …

Renowned for their regenerative abilities, axolotls also exhibit exceptional longevity,
resistance to age-related diseases and apparent lack of physiological declines through …

Scientists are forever searching for ways to rejuvenate aged cells and organisms back to a
more youthful and healthier state—from stem cell therapies to telomere lengthening, or even …