The cells and tissues of the human body are constantly exposed to exogenous and
endogenous forces that are referred to as biomechanical cues. They guide and impact …

Mechanical forces are essential contributors to and unavoidable components of cardiac
formation, both inducing and orchestrating local and global molecular and cellular changes …

Rationale: Primary cilia are cellular protrusions that serve as mechanosensors for fluid flow.
In endothelial cells (ECs), they function by transducing local blood flow information into …

Microcirculation (2010) 17, 164–178. doi: 10.1111/j. 1549‐8719.2010. 00025. x Abstract
Blood vessels have long been known to respond to hemodynamic force, and several …

This review will focus on two elements that are essential for functional arterial regeneration
in vitro: the mechanical environment and the bioreactors used for tissue growth. The …

Atrioventricular valve development commences with an EMT event whereby endocardial
cells transform into mesenchyme. The molecular events that induce this phenotypic change …

Heart valves are dynamic structures that open and close during the cardiac cycle to maintain
unidirectional blood flow throughout life. Insufficient valve function, commonly due to …

Biomechanics affect early cardiac development, from loo** to the development of
chambers and valves. Hemodynamic forces are essential for proper cardiac development …

The heart is the first functional organ in a develo** embryo. Cardiac development
continues throughout developmental stages while the heart goes through a serious of …

Hypoplastic left heart syndrome (HLHS) is a clinically and anatomically severe form of
congenital heart disease; however, its etiology remains largely unknown. We previously …