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Deubiquitinases in cancer
Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …
Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials
Z Niu, R **, Y Zhang, H Li - Signal Transduction and Targeted Therapy, 2022 - nature.com
Lung cancer is the leading cause of cancer-related death across the world. Unlike lung
adenocarcinoma, patients with lung squamous cell carcinoma (LSCC) have not benefitted …
adenocarcinoma, patients with lung squamous cell carcinoma (LSCC) have not benefitted …
USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer
Deubiquitylating enzymes (DUBs) play an essential role in targeted protein degradation and
represent an emerging therapeutic paradigm in cancer. However, their therapeutic potential …
represent an emerging therapeutic paradigm in cancer. However, their therapeutic potential …
Protein degradation: expanding the toolbox to restrain cancer drug resistance
Despite significant progress in clinical management, drug resistance remains a major
obstacle. Recent research based on protein degradation to restrain drug resistance has …
obstacle. Recent research based on protein degradation to restrain drug resistance has …
TRIM21 induces selective autophagic degradation of c-Myc and sensitizes regorafenib therapy in colorectal cancer
WL Ye, L Huang, XQ Yang, S Wan, WJ Gan… - Proceedings of the …, 2024 - pnas.org
Kirsten rat sarcoma virus (KRAS) mutation is associated with malignant tumor transformation
and drug resistance. However, the development of clinically effective targeted therapies for …
and drug resistance. However, the development of clinically effective targeted therapies for …
USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer
SREBP2 is a master regulator of the mevalonate pathway (MVP), a biosynthetic process that
drives the synthesis of dolichol, heme A, ubiquinone and cholesterol and also provides …
drives the synthesis of dolichol, heme A, ubiquinone and cholesterol and also provides …
Structural basis for the bi-specificity of USP25 and USP28 inhibitors
The development of cancer therapeutics is often hindered by the fact that specific
oncogenes cannot be directly pharmaceutically addressed. Targeting deubiquitylases that …
oncogenes cannot be directly pharmaceutically addressed. Targeting deubiquitylases that …
PTBP1 drives c-Myc-dependent gastric cancer progression and stemness
T Ni, Z Chu, L Tao, Y Zhao, M Zhu, Y Luo… - British Journal of …, 2023 - nature.com
Background Gastric cancer (GC) tumorigenesis and treatment failure are caused by cancer
stem cells. Polypyrimidine tract binding protein 1 (PTBP1) was shown to be involved in the …
stem cells. Polypyrimidine tract binding protein 1 (PTBP1) was shown to be involved in the …
Ubiquitin-specific protease 28: the decipherment of its dual roles in cancer development
X Ren, M Jiang, P Ding, X Zhang, X Zhou… - … Hematology & Oncology, 2023 - Springer
As significant posttranslational modifications, ubiquitination and deubiquitination, whose
balance is modulated by ubiquitin-conjugating enzymes and deubiquitinating enzymes …
balance is modulated by ubiquitin-conjugating enzymes and deubiquitinating enzymes …
Recent advances in the development of deubiquitinases inhibitors as antitumor agents
LL Zheng, LT Wang, YW Pang, LP Sun, L Shi - European Journal of …, 2024 - Elsevier
Ubiquitination is a type of post-translational modification that covalently links ubiquitin to a
target protein, which plays a critical role in modulating protein activity, stability, and …
target protein, which plays a critical role in modulating protein activity, stability, and …