Glycoproteomics

I Bagdonaite, SA Malaker, DA Polasky… - Nature Reviews …, 2022 - nature.com
Protein glycosylation involves the co-translational or post-translational addition of glycans to
proteins and is a crucial protein modification in health and disease. The aim of …

[HTML][HTML] A pragmatic guide to enrichment strategies for mass spectrometry–based glycoproteomics

NM Riley, CR Bertozzi, SJ Pitteri - Molecular & Cellular Proteomics, 2021 - Elsevier
Glycosylation is a prevalent, yet heterogeneous modification with a broad range of
implications in molecular biology. This heterogeneity precludes enrichment strategies that …

Chemical glycoproteomics

KK Palaniappan, CR Bertozzi - Chemical reviews, 2016 - ACS Publications
Chemical tools have accelerated progress in glycoscience, reducing experimental barriers
to studying protein glycosylation, the most widespread and complex form of posttranslational …

Mammalian brain glycoproteins exhibit diminished glycan complexity compared to other tissues

SE Williams, M Noel, S Lehoux, M Cetinbas… - Nature …, 2022 - nature.com
Glycosylation is essential to brain development and function, but prior studies have often
been limited to a single analytical technique and excluded region-and sex-specific analyses …

The challenge and promise of glycomics

RD Cummings, JM Pierce - Chemistry & biology, 2014 - cell.com
Glycomics is a broad and emerging scientific discipline focused on defining the structures
and functional roles of glycans in biological systems. The staggering complexity of the …

Oligosaccharide synthesis and translational innovation

L Krasnova, CH Wong - Journal of the American Chemical Society, 2019 - ACS Publications
The translation of biological glycosylation in humans to the clinical applications involves
systematic studies using homogeneous samples of oligosaccharides and glycoconjugates …

Recent advances in glycoproteomic analysis by mass spectrometry

S Suttapitugsakul, F Sun, R Wu - Analytical chemistry, 2019 - ACS Publications
Glycosylation is one of the most common protein modifications and is essential for cells. This
modification is exceptionally complex because glycans are highly diverse and can be …

Structural basis of adhesive binding by desmocollins and desmogleins

OJ Harrison, J Brasch, G Lasso, PS Katsamba… - Proceedings of the …, 2016 - pnas.org
Desmosomes are intercellular adhesive junctions that impart strength to vertebrate tissues.
Their dense, ordered intercellular attachments are formed by desmogleins (Dsgs) and …

Mannose metabolism: more than meets the eye

V Sharma, M Ichikawa, HH Freeze - Biochemical and biophysical research …, 2014 - Elsevier
Mannose is a simple sugar with a complex life. It is a welcome therapy for genetic and
acquired human diseases, but it kills honeybees and blinds baby mice. It could cause …

Neurological aspects of human glycosylation disorders

HH Freeze, EA Eklund, BG Ng… - Annual review of …, 2015 - annualreviews.org
This review presents principles of glycosylation, describes the relevant glycosylation
pathways and their related disorders, and highlights some of the neurological aspects and …