Dopamine, immunity, and disease
B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - Elsevier
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …
regulating many processes including reward, movement, and cognition. Dopamine also …
The systemic immune response in Parkinson's disease: Focus on the peripheral immune component
J Lauritsen, M Romero-Ramos - Trends in neurosciences, 2023 - cell.com
During Parkinson's disease (PD), both the central nervous system (CNS) and peripheral
nervous system (PNS) are affected. In parallel, innate immune cells respond early to …
nervous system (PNS) are affected. In parallel, innate immune cells respond early to …
[HTML][HTML] The complex role of inflammation and gliotransmitters in Parkinson's disease
Our understanding of the role of innate and adaptive immune cell function in brain health
and how it goes awry during aging and neurodegenerative diseases is still in its infancy …
and how it goes awry during aging and neurodegenerative diseases is still in its infancy …
DAT and TH expression marks human Parkinson's disease in peripheral immune cells
Parkinson's disease (PD) is marked by a loss of dopamine neurons, decreased dopamine
transporter (DAT) and tyrosine hydroxylase (TH) expression. However, this validation …
transporter (DAT) and tyrosine hydroxylase (TH) expression. However, this validation …
Dopamine and norepinephrine are embracing their immune side and so should we
PJ Gaskill, H Khoshbouei - Current opinion in neurobiology, 2022 - Elsevier
While the history of neuroimmunology is long, the explicit study of neuroimmune
communication, and particularly the role of catecholamines in neuroimmunity, is still …
communication, and particularly the role of catecholamines in neuroimmunity, is still …
[HTML][HTML] Monoamine oxidases: A missing link between mitochondria and inflammation in chronic diseases?
The role of mitochondria spans from the regulation of the oxidative phosphorylation, cell
metabolism and survival/death pathways to a more recently identified function in chronic …
metabolism and survival/death pathways to a more recently identified function in chronic …
Who knew? Dopamine transporter activity is critical in innate and adaptive immune responses
A Gopinath, PM Mackie, LT Phan, R Mirabel, AR Smith… - Cells, 2023 - mdpi.com
The dopamine transporter (DAT) regulates the dimension and duration of dopamine
transmission. DAT expression, its trafficking, protein–protein interactions, and its activity are …
transmission. DAT expression, its trafficking, protein–protein interactions, and its activity are …
Development of a Fluorescently Labeled Ligand for Rapid Detection of DAT in Human and Mouse Peripheral Blood Monocytes
GA Camacho-Hernandez, A Gopinath, AV Okorom… - JACS Au, 2024 - ACS Publications
The dopamine transporter (DAT) is one of the key regulators of dopamine (DA) signaling in
the central nervous system (CNS) and in the periphery. Recent reports in a model of …
the central nervous system (CNS) and in the periphery. Recent reports in a model of …
Substance P promotes epidural fibrosis via induction of type 2 macrophages
F Hua, HR Wang, YF Bai, JP Sun… - Neural Regeneration …, 2023 - journals.lww.com
In response to spinal surgery, neurons secrete a large amount of substance P into the
epidural area. Substance P is involved in macrophage differentiation and fibrotic disease …
epidural area. Substance P is involved in macrophage differentiation and fibrotic disease …
Leaky lessons learned: Efflux prone dopamine transporter variant reveals sex and circuit specific contributions of D2 receptor signalling to neuropsychiatric disease
Aberrant dopamine (DA) signalling has been implicated in various neuropsychiatric
disorders, including attention‐deficit/hyperactivity disorder (ADHD), autism spectrum …
disorders, including attention‐deficit/hyperactivity disorder (ADHD), autism spectrum …