Two of the most prevalent human viruses worldwide, herpes simplex virus type 1 and type 2
(HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital …

A large proportion of memory T cells disseminated throughout the body are non‐
recirculating cells whose maintenance and function is regulated by tissue‐specific …

Most herpes simplex virus 2 (HSV-2) reactivations in humans are subclinical and associated
with rapid expansion and containment of virus. Previous studies have shown that CD8+ T …

Mucosal surfaces provide a remarkably effective barrier against potentially dangerous
pathogens. Therefore, enhancing mucosal immunity through vaccines—strengthening that …

Herpes simplex viruses are ubiquitous human pathogens represented by two distinct
serotypes: herpes simplex virus (HSV) type 1 (HSV-1); and HSV type 2 (HSV-2). In the …

Abstract Herpes simplex virus-2 (HSV-2) is periodically shed throughout the human genital
tract. Although a high viral load correlates with the development of genital ulcers, shedding …

The mechanisms underlying rapid elimination of herpes simplex virus-2 (HSV-2) in the
human genital tract despite low CD8+ and CD4+ tissue-resident T cell (Trm cell) density are …

Changes in T cell trafficking accompany the naive to memory T cell antigen-driven
differentiation, which remains an incompletely defined developmental step. Upon priming …

IL-32 is a recently described cytokine that performs a variety of functions under inflammatory
conditions. Serum IL-32 has been shown to be elevated in several diseases, including type …

Chronic viral infections are known to lead to T cell exhaustion or dysfunction. However, it
remains unclear if antigen exposure episodes from periodic viral reactivation, such as …