Histone methylation can occur at various sites in histone proteins, primarily on lysine and
arginine residues, and it can be governed by multiple positive and negative regulators, even …

As a component of the response to acute stress, p53 has a well established role in
protecting against cancer development. However, it is now becoming clear that p53 can …

The presence of ribonucleotides in genomic DNA is undesirable given their increased
susceptibility to hydrolysis. Ribonuclease (RNase) H enzymes that recognize and process …

Publisher Summary The p53 protein is a tight, hydrophobic central globule containing the
DNA binding domain, flanked by accessible N-and C-terminal regions. This protein is …

Apoptotic cells are commonly observed in a broad range of tissues during mammalian
embryonic and fetal development. Specific requirements and functions of programmed cell …

The “four core genotypes”(FCG) model comprises mice in which sex chromosome
complement (XX vs. XY) is unrelated to the animal's gonadal sex. The four genotypes are XX …

Subsequently, with the evolution of longerliving organisms, p53 is thought to have acquired
the ability to respond to oncogenic signals, promoting apoptosis or senescence–a …

The p53 pathway is composed of hundreds of genes and their products that respond to a
wide variety of stress signals. These responses to stress include apoptosis, cellular …

TP53 is the most frequently mutated tumor suppressor gene in human cancer, with nearly
50% of all tumors exhibiting a loss-of-function mutation. To further elucidate the genetic …

The p53 protein has been extensively studied for its capacity to prevent proliferation of cells
with a damaged genome. Surprisingly, however, our recent analysis of mice expressing a …