Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …

Maintenance of systemic homeostasis and the response to nutritional and environmental
challenges require the coordination of multiple organs and tissues. To respond to various …

Ghrelin, a gastric-derived acylated peptide, regulates energy homeostasis by transmitting
information about peripheral nutritional status to the brain, and is essential for protecting …

Obesity increases hepatocellular carcinoma (HCC) risks via unknown mediators. We report
that hepatic unconventional prefoldin RPB5 interactor (URI) couples nutrient surpluses to …

In addition to ghrelin's effects on appetite and adiposity, ghrelin signalling also plays crucial
roles in glucose and energy homeostasis, cardioprotection, muscle atrophy and bone …

The a 28-amino acid peptide ghrelin was discovered in 1999 as a growth hormone (GH)
releasing peptide. Soon after its discovery, ghrelin was found to increase body weight and …

Food intake, energy expenditure and body adiposity are homeostatically regulated. Central
and peripheral signals communicate information about the current state of energy balance to …

The mechanisms for controlling food intake involve mainly an interplay between gut, brain,
and adipose tissue (AT), among the major organs. Parasympathetic, sympathetic, and other …

Considered the definitive source in its field for over 35 years, Endocrinology: Adult and
Pediatric, has been thoroughly updated to reflect today's recent advances in adult and …

The peptide hormone ghrelin is the only known protein modified with an O-linked octanoyl
side group, which occurs on its third serine residue. This modification is crucial for ghrelin's …