Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Globally, diabetes is the leading cause of chronic kidney disease and end-stage renal
disease, which are major risk factors for cardiovascular disease and death. Despite this …

Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions.
AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning …

Sirt1 is the most prominent and extensively studied member of sirtuins, the family of
mammalian class III histone deacetylases heavily implicated in health span and longevity …

Since the beginning of the century, the mammalian sirtuin protein family (comprising SIRT1–
SIRT7) has received much attention for its regulatory role, mainly in metabolism and ageing …

Resveratrol has emerged in recent years as a compound conferring strong protection
against metabolic, cardiovascular and other age-related complications, including …

The complexity of human DNA has been affected by aerobic metabolism, including
endurance exercise and oxygen toxicity. Aerobic endurance exercise could play an …

Obesity can cause a decline in contractile function of skeletal muscle, thereby reducing
mobility and promoting obesity-associated health risks. We reviewed the literature to …

Concurrent training is defined as simultaneously incorporating both resistance and
endurance exercise within a periodized training regime. Despite the potential additive …

Increased oxidative stress has been associated with the aging process. However, recent
studies have revealed that a low-level oxidative stress can even extend the lifespan of …