Inhibiting extracellular vesicles formation and release: a review of EV inhibitors

M Catalano, L O'Driscoll - Journal of extracellular vesicles, 2020 - Taylor & Francis
It is now becoming well established that vesicles are released from a broad range of cell
types and are involved in cell-to-cell communication, both in physiological and pathological …

Extracellular vesicles and particles impact the systemic landscape of cancer

S Lucotti, CM Kenific, H Zhang, D Lyden - The EMBO journal, 2022 - embopress.org
Intercellular cross talk between cancer cells and stromal and immune cells is essential for
tumor progression and metastasis. Extracellular vesicles and particles (EVPs) are a …

A comparison of methods for the isolation and separation of extracellular vesicles from protein and lipid particles in human serum

K Brennan, K Martin, SP FitzGerald, J O'sullivan… - Scientific reports, 2020 - nature.com
Extracellular vesicles (EVs) are nano-sized vesicles containing nucleic acid and protein
cargo that are released from a multitude of cell types and have gained significant interest as …

Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment

S Tan, Y Yang, W Yang, Y Han, L Huang… - Journal of Experimental …, 2023 - Springer
Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the
tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet …

Tumor-derived exosomes in the regulation of macrophage polarization

MS Baig, A Roy, S Rajpoot, D Liu, R Savai… - Inflammation …, 2020 - Springer
Background This review focuses on exosomes derived from various cancer cells. The review
discusses the possibility of differentiating macrophages in alternatively activated anti …

Scalable production of human mesenchymal stromal cell-derived extracellular vesicles under serum-/xeno-free conditions in a microcarrier-based bioreactor culture …

M de Almeida Fuzeta, N Bernardes… - Frontiers in Cell and …, 2020 - frontiersin.org
Mesenchymal stromal cells (MSC) hold great promise for tissue engineering and cell-based
therapies due to their multilineage differentiation potential and intrinsic immunomodulatory …

Hypoxia-driven effects in cancer: characterization, mechanisms, and therapeutic implications

R Shi, C Liao, Q Zhang - Cells, 2021 - mdpi.com
Hypoxia, a common feature of solid tumors, greatly hinders the efficacy of conventional
cancer treatments such as chemo-, radio-, and immunotherapy. The depletion of oxygen in …

Hypoxia in tumor microenvironment regulates exosome biogenesis: Molecular mechanisms and translational opportunities

A Kumar, G Deep - Cancer letters, 2020 - Elsevier
Hypoxia is a key feature of solid tumors, associated with disease aggressiveness and poor
outcome. Besides undergoing broad intracellular molecular and metabolic adaptations …

Milk-derived extracellular vesicles in inter-organism, cross-species communication and drug delivery

R Sanwlani, P Fonseka, SV Chitti, S Mathivanan - Proteomes, 2020 - mdpi.com
Milk is considered as more than a source of nutrition for infants and is a vector involved in
the transfer of bioactive compounds and cells. Milk contains abundant quantities of …

Dissecting exosome inhibitors: therapeutic insights into small-molecule chemicals against cancer

JH Kim, CH Lee, MC Baek - Experimental & Molecular Medicine, 2022 - nature.com
Intensive research in the field of cancer biology has revealed unique methods of
communication between cells through extracellular vesicles called exosomes. Exosomes …