A significant challenge in the current orthopedics is the development of suitable
osteobiologic materials that can replace the conventional allografts, autografts, and …

Since bone tissue lesions caused by several reasons and has global outbreak without any
attentions to the modernity level of the countries. In the other hands treatment of patients with …

Tissue engineering is a promising alternative to autografts or allografts for the regeneration
of large bone defects. Cell-free biomaterials with different degrees of sophistication can be …

Background Stem cell-based bone tissue engineering shows promise for bone repair but
faces some challenges, such as insufficient osteogenesis and limited architecture flexibility …

Mesenchymal stromal cells (MSCs) are multipotent cells that can give rise to different cell
types of the mesodermal lineages. They are powerful sources for cell therapy in …

The development of bone substitute materials (BSMs) intended for load-bearing bone
defects is highly complicated, as biological and mechanical requirements are often …

Bone loss resulting from degenerative diseases and trauma is a significant clinical burden
which is likely to grow exponentially with the aging population. In a number of conditions …

Growth factor delivery using acellular matrices presents a promising alternative to current
treatment options for bone repair in critical-size injuries. However, supra-physiological …

Electrospun fibrous scaffolds have attracted much research interest due to their many
applications in orthopedics and other relevant fields. However, poor surface bioactivity of the …

Mandibular defects, caused by congenital, pathological or iatrogenic insults, can
significantly affect patient quality of life. The reconstruction of mandible has recently gained …