Changes in the properties and postsynaptic abundance of AMPA-type glutamate receptors
(AMPARs) are major mechanisms underlying various forms of synaptic plasticity, including …

O-GlcNAcylation—the attachment of O-linked N-acetylglucosamine (O-GlcNAc) moieties to
cytoplasmic, nuclear and mitochondrial proteins—is a post-translational modification that …

In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …

Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …

O-GlcNAcylation is a posttranslational modification that adds O-linked β-N-
acetylglucosamine (O-GlcNAc) to serine or threonine residues of many proteins. This protein …

Major depressive disorder is a common and devastating psychiatric disease, and the
prevalence and burden are substantially increasing worldwide. Multiple studies of …

Glycosylation, the addition of glycans or carbohydrates to proteins, lipids, or other glycans, is
a complex post-translational modification that plays a crucial role in cellular function. It is …

Alzheimer disease (AD) is a growing problem for aging populations worldwide. Despite
significant efforts, no therapeutics are available that stop or slow progression of AD, which …

O-GlcNAc glycosylation (or O-GlcNAcylation) is a dynamic, inducible posttranslational
modification found on proteins associated with neurodegenerative diseases such as α …

O-GlcNAcylation, a dynamic nutrient and stress sensitive post-translational modification,
occurs on myriad proteins in the cell nucleus, cytoplasm and mitochondria. O-GlcNAcylation …