Curcumin, a yellow substance belonging to the polyphenols superfamily, is the active
component of turmeric, a common Indian spice, which is derived from the dried rhizome of …

Members of the signal transducers and activators of transcription (STAT) pathway, which
were originally identified as key components linking cytokine signals to transcriptional …

Physiological levels of Kras G12D are sufficient to induce pancreatic intraepithelial
neoplasias (PanINs); the mechanisms that drive PanIN progression are unknown. Here, we …

Resistance to pharmacologic agents used in chemotherapy is common in most human
carcinomas, including pancreatic ductal adenocarcinoma (PDA), which is resistant to almost …

Gemcitabine is currently the best treatment available for pancreatic cancer, but the disease
develops resistance to the drug over time. Agents that can either enhance the effects of …

BACKGROUND & AIMS: Early metastasis is a hallmark of pancreatic ductal
adenocarcinoma and responsible for> 90% of pancreatic cancer death. Because little is …

Recent evidence indicates a convergence of molecular targets for both prevention and
therapy of cancer. Signal‐transducer‐and‐activator‐of‐transcription‐3 (STAT3), a member …

One of the primary diseases that cause death worldwide is cancer. Cancer cells can be
intrinsically resistant or acquire resistance to therapies and drugs used for cancer treatment …

Curcumin, used as a spice and traditional medicine in India, exerts beneficial effects against
several diseases, owing to its antioxidant, analgesic, and anti-inflammatory properties …

One of the defining features of pancreatic ductal adenocarcinoma (PDAC) is the presence of
extensive desmoplasia. The desmoplastic stroma consists of proliferating fibroblasts and …