Nicotine sustains tobacco addiction, a major cause of disability and premature death.
Nicotine binds to nicotinic cholinergic receptors, facilitating neurotransmitter release and …

Anatomical and functional refinements of the meso-limbic dopamine system of the rat are
discussed. Present experiments suggest that dopaminergic neurons localized in the …

Dopamine is involved in drug reinforcement but its role in addiction is less clear. Here we
describe PET imaging studies that investigate dopamine's involvement in drug abuse in the …

Rationale This review provides insight for the judicious selection of nicotine dose ranges
and routes of administration for in vivo studies. The literature is replete with reports in which …

Some psychoactive drugs are abused because of their ability to act as reinforcers. As a
consequence behavioural patterns (such as drug‐seeking/drug‐taking behaviours) are …

Nicotine sustains addictive tobacco use, which in turn causes much premature disability and
death. The essence of drug addiction is loss of control of drug use. Molecular biology studies …

Addiction is a complex disease that impacts millions of people around the world. Clinically,
addiction is formalized as substance use disorder (SUD), with three primary symptom …

Cigarette smoking is a leading cause of mortality and morbidity and a particularly common
and intractable addictive disorder. Research shows that nicotine is a sine qua non of …

Rationale A great deal of research supports the role of nicotine in cigarette addiction.
However, the effectiveness of nicotine replacement therapy (NRT) as a smoking cessation …

Tobacco use is associated with 5 million deaths per year worldwide and is regarded as one
of the leading causes of premature death. Comprehensive programmes for tobacco control …