Sepsis is a multisystem disease characterized by dysregulation of the host immune
response to infection. Immune response kinetics play a crucial role in the pathogenesis and …

Purpose Natural history studies have been informative in dissecting radiation injury,
isolating its effects, and compartmentalizing injury based on the extent of exposure and the …

The hematopoietic system is highly sensitive to ionizing radiation. Damage to the immune
system may result in opportunistic infections and hemorrhage, which could lead to mortality …

Novel therapeutics are urgently needed to prevent opportunistic infections in
immunocompromised individuals undergoing cancer treatments or other immune …

Exposure to ionizing radiation causes acute damage and loss of bone marrow and
peripheral immune cells that can result in high mortality due to reduced resistance to …

In this study, we leveraged a combination of single cell RNAseq, cytometry by time of flight
(CyTOF), and flow cytometry to study the biology of a unique macrophage population in …

There is a need for countermeasures to mitigate lethal acute radiation syndrome (ARS) and
delayed effects of acute radiation exposure (DEARE). In WAG/RijCmcr rats, ARS occurs by …

Innate training of macrophages can be beneficial for the clearance of pathogens. However,
for certain chronic conditions, innate training can have detrimental effects due to an …

The growth of antimicrobial resistance (AMR) has highlighted an urgent need to identify
bacterial pathogenic functions that may be targets for clinical intervention. Although severe …

The growth of antimicrobial resistance (AMR) highlights an urgent need to identify bacterial
pathogenic functions that may be targets for clinical intervention. Although severe infections …