The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications
In some patients with major depressive disorder (MDD), individual illness characteristics
appear consistent with those of a neuroprogressive illness. Features of neuroprogression …
appear consistent with those of a neuroprogressive illness. Features of neuroprogression …
Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics
Deciphering what governs inflammation and its effects on tissues is vital for understanding
many pathologies. The recent discovery that glycogen synthase kinase-3 (GSK3) promotes …
many pathologies. The recent discovery that glycogen synthase kinase-3 (GSK3) promotes …
Depressive-like behavior induced by tumor necrosis factor-α in mice
Pro-inflammatory cytokines are implicated in the pathogenesis of depression. However, few
animal models of cytokine-induced depression well characterized regarding its response to …
animal models of cytokine-induced depression well characterized regarding its response to …
A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder
RA Khairova, R Machado-Vieira, J Du… - International Journal of …, 2009 - academic.oup.com
A growing body of data suggests that hyperactivation of the immune system has been
implicated in the pathophysiology of major depressive disorder (MDD). Several pro …
implicated in the pathophysiology of major depressive disorder (MDD). Several pro …
The hippocampus and TNF: Common links between chronic pain and depression
Major depression and chronic pain are significant health problems that seriously impact the
quality of life of affected individuals. These diseases that individually are difficult to treat …
quality of life of affected individuals. These diseases that individually are difficult to treat …
Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder
H Anisman - Journal of Psychiatry and Neuroscience, 2009 - jpn.ca
Activation of the inflammatory immune system provokes numerous neuroendocrine and
neurotransmitter changes, many of which are similar to those provoked by physical or …
neurotransmitter changes, many of which are similar to those provoked by physical or …
Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: comorbidity between depression and neurodegenerative disorders
Given the array of biological changes induced by stressors, it is not surprising that these
experiences may provoke a variety of illnesses. Among others things, stressors promote …
experiences may provoke a variety of illnesses. Among others things, stressors promote …
Neuronal damage and protection in the pathophysiology and treatment of psychiatric illness: stress and depression
RS Duman - Dialogues in clinical neuroscience, 2009 - Taylor & Francis
The discovery that stress and depression, as well as other psychiatric illnesses, are
characterized by structural alterations, and that these changes result from atrophy and loss …
characterized by structural alterations, and that these changes result from atrophy and loss …
Anti-inflammatory properties of desipramine and fluoxetine
C Roumestan, A Michel, F Bichon, K Portet, M Detoc… - Respiratory …, 2007 - Springer
Background Antidepressants are heavily prescribed drugs and have been shown to affect
inflammatory signals. We examined whether these have anti-inflammatory properties in …
inflammatory signals. We examined whether these have anti-inflammatory properties in …
Towards host-directed therapies for tuberculosis
A Zumla, J Chakaya, M Hoelscher, F Ntoumi… - Nature reviews Drug …, 2015 - nature.com
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