The granzymes are cell death–inducing enzymes, stored in the cytotoxic granules of
cytotoxic T lymphocytes and natural killer cells, that are released during granule exocytosis …

Granzyme A (GzmA) is the most abundant serine protease in killer cell cytotoxic granules.
GzmA activates a novel programed cell death pathway that begins in the mitochondrion …

Proteins display a hierarchy of structural features at primary, secondary, tertiary, and higher-
order levels, an organization that guides our current understanding of their biological …

The killer lymphocyte protease granzyme A (GzmA) triggers caspase-independent target cell
death with morphological features of apoptosis. We previously showed that GzmA acts …

Granzyme A (GrA) has long been recognized as one of the key players in the induction of
cell death of neoplastic, foreign or infected cells after granule delivery by cytotoxic cells …

Granzyme A, a serine protease in the cytotoxic granules of natural killer cells and cytotoxic T
lymphocytes, induces caspase-independent cell death when introduced into target cells by …

Approximately 2% of mammalian genes encode proteases. Comparative genomics reveals
that those involved in immunity and reproduction show the most interspecies diversity and …

NK cells and cytotoxic T lymphocytes can induce apoptosis in virus‐infected and
transformed target cells via the granule exocytosis pathway. The key components of the …

Cytotoxic immune cells, including T lymphocytes (CTLs) and natural killer (NK) cells, are
essential components of the host response against tumors. CTLs and NK cells secrete …

Granzyme K (GzmK) is a tryptic member of the granzyme family of chymotrypsin-like serine
proteases produced by cells of the immune system. Previous studies have indicated that …