Interlinked fast and slow positive feedback loops drive reliable cell decisions
Positive feedback is a ubiquitous signal transduction motif that allows systems to convert
graded inputs into decisive, all-or-none outputs. Here we investigate why the positive …
graded inputs into decisive, all-or-none outputs. Here we investigate why the positive …
The effects of immune system modulation on prion disease susceptibility and pathogenesis
Prion diseases are a unique group of infectious chronic neurodegenerative disorders to
which there are no cures. Although prion infections do not stimulate adaptive immune …
which there are no cures. Although prion infections do not stimulate adaptive immune …
A 25 nm virion is the likely cause of transmissible spongiform encephalopathies
L Manuelidis - Journal of cellular biochemistry, 2007 - Wiley Online Library
The transmissible spongiform encephalopathies (TSEs) such as endemic sheep scrapie,
sporadic human Creutzfeldt‐Jakob disease (CJD), and epidemic bovine spongiform …
sporadic human Creutzfeldt‐Jakob disease (CJD), and epidemic bovine spongiform …
Chronic neurodegeneration induces type I interferon synthesis via STING, sha** microglial phenotype and accelerating disease progression
Abstract Type I interferons (IFN‐I) are the principal antiviral molecules of the innate immune
system and can be made by most cell types, including central nervous system cells. IFN‐I …
system and can be made by most cell types, including central nervous system cells. IFN‐I …
[HTML][HTML] Systemic challenge with the TLR3 agonist poly I: C induces amplified IFNα/β and IL-1β responses in the diseased brain and exacerbates chronic …
R Field, S Campion, C Warren, C Murray… - Brain, behavior, and …, 2010 - Elsevier
The role of inflammation in the progression of neurodegenerative disease remains unclear.
We have shown that systemic bacterial insults accelerate disease progression in animals …
We have shown that systemic bacterial insults accelerate disease progression in animals …
Functionalized nanoparticles with monocyte membranes and rapamycin achieve synergistic chemoimmunotherapy for reperfusion-induced injury in ischemic stroke
Y Wang, Y Wang, S Li, Y Cui, X Liang, J Shan… - Journal of …, 2021 - Springer
Background Ischemic stroke is an acute and severe neurological disease, and reperfusion is
an effective way to reverse brain damage after stroke. However, reperfusion causes …
an effective way to reverse brain damage after stroke. However, reperfusion causes …
A versatile prion replication assay in organotypic brain slices
J Falsig, C Julius, I Margalith, P Schwarz… - Nature …, 2008 - nature.com
Methods enabling prion replication ex vivo are important for advancing prion studies.
However, few such technologies exist, and many prion strains are not amenable to them …
However, few such technologies exist, and many prion strains are not amenable to them …
Gene expression profiling of scrapie-infected brain tissue
C Riemer, S Neidhold, M Burwinkel, A Schwarz… - Biochemical and …, 2004 - Elsevier
The underlying pathomechanisms in prion infections of the central nervous system are still
insufficiently understood. The identification of genes with altered expression patterns in the …
insufficiently understood. The identification of genes with altered expression patterns in the …
Interferon-γ increases neuronal death in response to amyloid-β1-42
C Bate, S Kempster, V Last, A Williams - Journal of neuroinflammation, 2006 - Springer
Background Alzheimer's disease is a neurodegenerative disorder characterized by a
progressive cognitive impairment, the consequence of neuronal dysfunction and ultimately …
progressive cognitive impairment, the consequence of neuronal dysfunction and ultimately …
Prion disease and the innate immune system
Prion diseases or transmissible spongiform encephalopathies are a unique category of
infectious protein-misfolding neurodegenerative disorders. Hypothesized to be caused by …
infectious protein-misfolding neurodegenerative disorders. Hypothesized to be caused by …