Overcoming skin barriers through advanced transdermal drug delivery approaches

V Phatale, KK Vaiphei, S Jha, D Patil, M Agrawal… - Journal of controlled …, 2022 - Elsevier
Upon exhaustive research, the transdermal drug delivery system (TDDS) has appeared as a
potential, well-accepted, and popular approach to a novel drug delivery system. Ease of …

Improved topical drug delivery: Role of permeation enhancers and advanced approaches

V Hmingthansanga, N Singh, S Banerjee, S Manickam… - Pharmaceutics, 2022 - mdpi.com
The delivery of drugs via transdermal routes is an attractive approach due to ease of
administration, bypassing of the first-pass metabolism, and the large skin surface area …

Development and optimization of curcumin analog nano-bilosomes using 21.31 full factorial design for anti-tumor profiles improvement in human hepatocellular …

H Abbas, YA El-Feky, MM Al-Sawahli, NM El-Deeb… - Drug …, 2022 - Taylor & Francis
Curcumin (CU) is a natural polyphenolic phytoingredient. CU has anti-inflammatory, anti-
oxidant, and anticancer activities. The poor solubility, bioavailability, and stability of CU …

A brain-targeted approach to ameliorate memory disorders in a sporadic alzheimer's disease mouse model via intranasal luteolin-loaded nanobilosomes

MA Elsheikh, YA El-Feky, MM Al-Sawahli, ME Ali… - Pharmaceutics, 2022 - mdpi.com
Impaired memory and cognitive function are the main features of Alzheimer's disease (AD).
Unfortunately, currently available treatments cannot cure or delay AD progression …

Challenges of current treatment and exploring the future prospects of nanoformulations for treatment of atopic dermatitis

V Kakkar, K Saini, KK Singh - Pharmacological Reports, 2023 - Springer
Atopic dermatitis (AD) is a predominant and deteriorating chronic inflammation of the skin,
categorized by a burning sensation and eczematous lesions in diverse portions of the body …

Full factorial design, physicochemical characterization, ex vivo investigation, and biological assessment of glutathione-loaded solid lipid nanoparticles for topical …

M Liu, M Sharma, GL Lu, Z Zhang, N Yin… - International journal of …, 2023 - Elsevier
Abstract l-Glutathione (GSH) has exceptional antioxidant activities against UVA irradiation-
induced oxidative stress and is used widely for combatting skin ageing. However, topical …

Recent updates on applications of lipid-based nanoparticles for site-specific drug delivery

S Agrawal, A Garg, V Varshney - Pharmaceutical …, 2022 - benthamdirect.com
Background: Site-specific drug delivery is a widespread and demanding area nowadays.
Lipid-based nanoparticulate drug delivery systems have shown promising effects for …

Fabrication, optimization, and evaluation of lyophilized lacidipine-loaded fatty-based nanovesicles as orally fast disintegrating sponge delivery system

RM El-Dahmy, AH Elshafeey, YA El-Feky - International Journal of …, 2024 - Elsevier
Lacidipine (LCD) is a potent antihypertensive agent. Fatty-based nanovesicles (FNVs) were
designed to improve LCD low solubility and bioavailability. LCD-FNVs were formulated …

Potential strategy of microneedle-based transdermal drug delivery system for effective management of skin-related immune disorders

P Xu, W **ao, K Xu, Y He, X Miao, Y Dong… - European Journal of …, 2024 - Elsevier
Skin-related immune disorders are a category of diseases that lead to the dysregulation of
the body's immune response due to imbalanced immune regulation. These disorders exhibit …

Cutaneous pharmacokinetics of topically applied novel dermatological formulations

M Patel, A Patel, J Desai, S Patel - AAPS PharmSciTech, 2024 - Springer
Novel formulations are developed for dermatological applications to address a wide range
of patient needs and therapeutic challenges. By pushing the limits of pharmaceutical …