Significance: The detrimental effects of ionizing radiation (IR) involve a highly orchestrated
series of events that are amplified by endogenous signaling and culminating in oxidative …

Solar UVB is carcinogenic. Nucleotide excision repair (NER) counteracts the carcinogenicity
of UVB by excising potentially mutagenic UVB-induced DNA lesions. Despite this capacity …

Tardigrades, also known as water bears, are small aquatic animals. Some tardigrade
species tolerate almost complete dehydration and exhibit extraordinary tolerance to various …

Loss of sexual reproduction is considered an evolutionary dead end for metazoans, but
bdelloid rotifers challenge this view as they appear to have persisted asexually for millions …

The bacterium Deinococcus radiodurans is a champion of extreme radiation resistance that
is accounted for by a highly efficient protection against proteome, but not genome, damage …

Increasingly, national space agencies are expanding their goals to include Mars exploration
with sample return. To better protect Earth and its biosphere from potential extraterrestrial …

Ageing is considered as a snowballing phenotype of the accumulation of damaged
dysfunctional or toxic proteins and silent mutations (polymorphisms) that sensitize relevant …

Bdelloid rotifers are part of the restricted circle of multicellular animals that can withstand a
wide range of genotoxic stresses at any stage of their life cycle. In this study, bdelloid rotifer …

Background Radiotherapy is a conventional and effective local treatment for breast cancer.
However, residual or recurrent tumors appears frequently because of radioresistance. Novel …

Bdelloid rotifers are microinvertebrates with unique characteristics: they have survived tens
of millions of years without sexual reproduction; they withstand extreme desiccation by …