Mitochondria are the powerhouses of the cell, whilst their malfunction is related to several
human pathologies, including neurodegenerative diseases, cardiovascular diseases, and …

Cardiolipin oxidation and degradation by different factors under severe cell stress serve as a
trigger for genetically encoded cell death programs. In this context, the interplay between …

Cytochrome c (cyt c) is a multifunctional protein with varying conformations. However, the
conformation of cyt c in its native environment, mitochondria, is still unclear. Here, we …

Aerobic life is based on numerous metabolic oxidation reactions as well as biosynthesis of
oxygenated signaling compounds. Among the latter are the myriads of oxygenated lipids …

Cardiolipin (CL) is an acidic phospholipid almost exclusively found in the inner
mitochondrial membrane, that not only stabilizes the structure and function of individual …

The high chemical diversity of lipids allows them to perform multiple biological functions
ranging from serving as structural building blocks of biological membranes to regulation of …

In addition to the known prominent role of polyunsaturated (phospho) lipids as structural
blocks of biomembranes, there is an emerging understanding of another important function …

The peroxidation of cardiolipins by reactive oxygen species, which is regulated and
enhanced by cytochrome c (cyt c), is a critical signaling event in mitochondrial apoptosis. We …

With the rapid development of society, the incidence of metabolic syndrome (MS) is
increasing rapidly. Evidence indicated that patients diagnosed with MS usually suffered from …

Cytochrome c (cyt-c) release from the mitochondria to the cytosol is a key process in the
initiation of hepatocyte apoptosis involved in the progression of non-alcoholic fatty liver …