Two-component systems (TCS) comprising sensor histidine kinases and response regulator
proteins are among the most important players in bacterial and archaeal signal transduction …

Two-component systems reprogramme diverse aspects of microbial physiology in response
to environmental cues. Canonical systems are composed of a transmembrane sensor …

Do the amino acid sequence identities of residues that make contact across protein
interfaces covary during evolution? If so, such covariance could be used to predict contacts …

Inverse problems in statistical physics are motivated by the challenges of 'big data'in
different fields, in particular high-throughput experiments in biology. In inverse problems, the …

Spatially proximate amino acids in a protein tend to coevolve. A protein's three-dimensional
(3D) structure hence leaves an echo of correlations in the evolutionary record. Reverse …

Co-evolution is a fundamental component of the theory of evolution and is essential for
understanding the relationships between species in complex ecological networks. A wide …

In the course of evolution, proteins undergo important changes in their amino acid
sequences, while their three-dimensional folded structure and their biological function …

The quantitative characterization of mutational landscapes is a task of outstanding
importance in evolutionary and medical biology: It is, for example, of central importance for …

Gram-negative pathogens such as Klebsiella pneumoniae, Acinetobacter baumannii, and
Pseudomonas aeruginosa are the leading cause of nosocomial infections throughout the …

Residue pairs that directly coevolve in protein families are generally close in protein 3D
structures. Here we study the exceptions to this general trend—directly coevolving residue …