Highly dynamic mitotic spindle microtubules are superb therapeutic targets for a group of
chemically diverse and clinically successful anticancer drugs. Microtubule-targeted drugs …

Covering: late 2008 to August 2013 Nature has yielded numerous classes of chemically
distinct microtubule stabilizers. Several of these, including paclitaxel (Taxol) and docetaxel …

Microtubules (MTs) are a highly successful target for anticancer therapy. MT-stabilizing
agents (MSAs) bind to MTs, promoting their polymerization, blocking mitosis, and causing …

During cell division, the receptor triple-negative MDA-MB-231 mitotic spindles are the
largest in comparison to other BC cell lines. Many of the MDA-MB-231 spindles exhibit rapid …

Background: A number of chemically diverse substances bind to the tubulin and inhibit cell
proliferation by disrupting microtubule dynamics. There are four binding sites for the ligands …

Marine natural products as secondary metabolites are a potential major source of new drugs
for treating disease. In some cases, cytotoxic marine metabolites target the microtubules of …

Covering: 2000 up to 2016 Peloruside A, a macrocyclic secondary metabolite from a New
Zealand marine sponge, Mycale hentscheli, has shown potent antiproliferative activity in …

Introduction: All degenerative diseases are associated with impairment in intracellular
trafficking. The highly dynamic organization and remodeling of the cellular cytoskeleton are …

Mitosis is one of the most fundamental processes of life by which a mammalian cell divides
into two daughter cells. Mitosis has been an attractive target for anticancer therapies since …

β-Tubulin is the target of benzimidazole fungicides, the most widely used of which is
carbendazim (methyl benzimidazol-2-ylcarbamate [MBC]). MBC sensitivity is determined by …