Progressive loss of physiological integrity and accumulation of degenerative changes
leading to functional impairment and increased susceptibility to diseases are the main …

Cumulus cell–oocyte communication is an essential feature of mammalian reproduction.
Established mechanisms involve the bidirectional transfer of ions and small molecules …

Noncoding RNAs (ncRNAs) have long been known to play vital roles in eukaryotic gene
regulation. Studies conducted over a decade ago revealed that maturation of spliced …

BACKGROUND Human long non-coding RNAs (lncRNAs) are an emerging category of
transcripts with increasingly documented functional roles during development. LncRNAs …

Context: It is hypothesized that obesity adversely affects the ovarian environment, which can
disrupt oocyte maturation and embryonic development. Objective: This study aimed to …

Abstract BACKGROUND Prostaglandin E2 (PGE2) is an essential intrafollicular regulator of
ovulation. In contrast with the one-gene, one-protein concept for synthesis of peptide …

Progress in assisted reproductive technologies strongly relies on understanding the
regulation of the dialogue between oocyte and cumulus cells (CCs). Little is known about …

Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility in
women of reproductive age, and its etiology remains poorly understood. Altered activities of …

Granulosa cells (GCs) are somatic cells surrounding oocytes within follicles and are
essential for folliculogenesis. Pathological changes in GCs are found in several ovarian …

The luteinizing hormone receptor (LHR) plays a pivotal role during follicular development.
Consequently, its expression pattern is of major importance for research and has clinical …